Effect of Intermittent Fasting Diet on Glucose and Lipid Metabolism and Insulin Resistance in Patients with Impaired Glucose and Lipid Metabolism: A Systematic Review and Meta-Analysis
Yuan X, Wang J, Yang S, Gao M, Cao L, Li X, Hong D, Tian S, Sun C
International journal of endocrinology · 69 citas
Cómo se estudió
- Diseño
- Metaanálisis (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- People's Government of Jilin Province
- Universidad u hospital
- Jilin University
- Gobierno
- Education Department of Jilin Province
- Gobierno
- Department of Science and Technology of Jilin Province
- Universidad u hospital
- First Hospital of Jilin University
- Subvenciones
- Jilin University (JJKH20201081KJ); Jilin University (JDYYJC010); Department of Science and Technology of Jilin Province (JJKH20190032KJ); Education Department of Jilin Province (20180623006TC); Education Department of Jilin Province (JJKH20201081KJ); Jilin University (JJKH20190032KJ); Jilin University (20180623006TC); Department of Science and Technology of Jilin Province (JDYYZH-1902019); Jilin University (20200404213YY); Department of Science and Technology of Jilin Province (JDYYJC010); Department of Science and Technology of Jilin Province (JJKH20201081KJ); Education Department of Jilin Province (20200404213YY); Jilin University (JDYYZH-1902019); Department of Science and Technology of Jilin Province (20200404213YY); Education Department of Jilin Province (JDYYZH-1902019); Education Department of Jilin Province (JJKH20190032KJ); Education Department of Jilin Province (JDYYJC010); Department of Science and Technology of Jilin Province (20180623006TC)
Según 5 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-03-24 · Int J Endocrinol · vol. 2022 · págs. 1–9
- Editorial
- Hindawi Publishing Corporation
- Citado
- 104 citas · más que el 95% de estudios similares · 3.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Diet and metabolism studies · Diet, Metabolism, and Disease
- Palabras clave
- Medicine, Insulin resistance, Lipid metabolism, Carbohydrate metabolism, Internal medicine, Endocrinology, Metabolism, Lipid profile, Fasting glucose, Insulin, Diabetes mellitus
9 autores
- Xiaojie Yuan🇨🇳Jilin University; First Hospital of Jilin University
- Jiping Wang🇨🇳Jilin University; First Hospital of Jilin University
- Shuo Yang🇨🇳Jilin University; First Hospital of Jilin University
- Mei Gao🇨🇳Jilin University; First Hospital of Jilin University
- Lingxia Cao🇨🇳Jilin University; First Hospital of Jilin University
- Xumei Li🇨🇳Jilin University; First Hospital of Jilin University
- Dongxu Hong🇨🇳Jilin University; First Hospital of Jilin University
- Suyan Tian🇨🇳 · autor de correspondenciaJilin University; First Hospital of Jilin University
- Chenglin Sun🇨🇳 · autor de correspondenciaJilin University; First Hospital of Jilin University
Resumen
El texto original del estudio, en el idioma en que se publicó.
The question of whether or not intermittent fasting diets improve the clinical indicators of glycolipid metabolism remains unclear. This study systematically reviewed the relevant clinical trials to evaluate the effects of intermittent fasting diet on glucose and lipid metabolism and insulin sensitivity in patients with metabolic syndrome. To evaluate the effect of intermittent fasting diet intervention on patients with disorders of glucose and lipid metabolism, random-effect or fixed-effect meta-analysis models were used to calculate the average difference before and after intermittent fasting diet intervention and the corresponding 95% confidence intervals (CIs). After intermittent fasting diet intervention, in terms of glucose metabolism, fasting blood glucose reduced by 0.15 mmol/L (95% CI: -0.23; -0.06), glycosylated hemoglobin reduced by 0.08 (95% CIs: -0.25; -0.10), insulin plasma levels reduced by 13.25 uUI (95% CIs: -16.69; -9.82), and HOMA-IR decreased by 0.31 on an average (95% CIs: -0.44; -0.19). In addition, BMI decreased by 0.8 kg/m2 (95% CIs: -1.32; -0.28), body weight reduced by 1.87 kg (95% CIs: -2.67; -1.07), and the waist circumference decreased by 2.08 cm (95% CIs: -3.06; -1.10). Analysis of lipid metabolism showed that intermittent fasting diet intervention effectively reduced the total cholesterol level by 0.32 mmol/L (95% CIs: -0.60; -0.05), low-density lipoprotein level by 0.22 mmol/L (95% CIs: -0.37; -0.07), and triglyceride level by 0.04 mmol/L (95% CIs: -0.15; -0.07). Intermittent fasting diets have certain therapeutic effects on blood glucose and lipids in patients with metabolic syndrome and significantly improve insulin resistance. It may be considered as an auxiliary treatment to prevent the occurrence and development of chronic diseases.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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