No evidence of differential impact of sunflower and rapeseed oil on biomarkers of coronary artery disease or chronic kidney disease in healthy adults with overweight and obesity: result from a randomised control trial
Nicol K, Mansoorian B, Latosinska A, Koutroulaki A, Mullen B, Combet E
European journal of nutrition · 7 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Posiblemente financiado por la industria
- Gobierno
- British Broadcasting Corporation
- Universidad u hospital
- University of Glasgow
- Autores
- Al menos un autor declara un vínculo económico con la industria
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-04-05 · Eur J Nutr · vol. 61 · número 6 · págs. 3119–3133
- Editorial
- Springer Science+Business Media
- Citado
- 12 citas · más que el 78% de estudios similares · 1.4× el promedio de su campo
- Referencias
- 30 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Edible Oils Quality and Analysis · Nutritional Studies and Diet
- Palabras clave
- sunflower oil, rapeseed oil, chronic kidney disease biomarkers, overweight, obesity, cardiometabolic health, 8-isoprostane, oxidative stress, glycation, inflammatory markers, serum lipids, fat replacement, proteomic biomarkers
- MeSH
- humans, helianthus, obesity, plant oils, proteomics, adult, overweight, renal insufficiency, chronic, coronary artery disease, biomarkers, sunflower oil, rapeseed oil
6 autores
- Katie Nicol🇬🇧Glasgow Royal Infirmary; University of Glasgow
- Bahareh Mansoorian🇬🇧Glasgow Royal Infirmary; University of Glasgow
- Agnieszka Latosińska🇩🇪Mosaiques Diagnostics and Therapeutics (Germany)
- Aimilia Koutroulaki🇬🇧Glasgow Royal Infirmary; University of Glasgow
- Bill Mullen🇬🇧University of Glasgow
- Emilie Combet🇬🇧 · autor de correspondenciaGlasgow Royal Infirmary; University of Glasgow
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
The perceived benefits and risks associated with seed oil intake remain controversial, with a limited number of studies investigating the impact of intake on a range of compounds used as cardiometabolic markers. This study aimed to explore the proteomic and cardiometabolic effects of commonly consumed seed oils in the UK, with different fatty acid profiles.
Methods
In a parallel randomised control design, healthy adults (n = 84), aged 25-72 with overweight or obesity were randomised to one of three groups: control (habitual diet, CON); 20 mL rapeseed oil per day (RO), or 20 mL sunflower oil per day (SO). Blood, spot urine and anthropometric measures were obtained at 0, 6 and 12 weeks. Proteomic biomarkers analysis was conducted for coronary arterial disease (CAD) and chronic kidney disease (CKD) using capillary electrophoresis coupled to mass spectrometry (CE-MS). Blood lipids, fasting blood glucose, glycative/oxidative stress and inflammatory markers were also analysed.
Results
No differences in change between time points were observed between groups for CAD or CKD peptide fingerprint scores. No change was detected within groups for CAD or CKD scores. No detectable differences were observed between groups at week 6 or 12 for the secondary outcomes, except median 8-isoprostane, ~ 50% higher in the SO group after 12-weeks compared to RO and CON groups (p = 0.03).
Conclusion
The replacement of habitual fat with either RO or SO for 12 weeks does not lead to an improvement or worsening in cardiovascular health markers in people with overweight or obesity.
Trial registration
Trial registration clinicaltrials.gov NCT04867629, retrospectively registered 30/04/2021.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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