Evaluation of the Effects of Oral Magnesium Sachet on the Prevention of Spinal Anesthesia-Induced Headache After Cesarean Section: A Randomized Clinical Trial
Nikooseresht M, Hajian P, Moradi A, Sanatkar M
Anesthesiology and pain medicine · 2 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2022-03-22 · Anesth Pain Med · vol. 12 · número 1 · pág. e121834
- Editorial
- Kowsar Medical (Netherlands)
- Citado
- 3 citas · más que el 65% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 39 trabajos
- Acceso
- Acceso abierto (publicación gratuita) · CC-BY-NC
- Áreas de investigación
- Anesthesia and Pain Management · Enhanced Recovery After Surgery · Preterm Birth and Chorioamnionitis
- Palabras clave
- Medicine, Anesthesia, Randomized controlled trial, Spinal anesthesia, Analgesic, Clinical trial, Complication, Magnesium, Pregnancy, Surgery, Internal medicine
4 autores
- Mahshid Nikooseresht🇮🇷Hamedan University of Medical Sciences
- Pouran Hajian🇮🇷 · autor de correspondenciaHamedan University of Medical Sciences
- Abas Moradi🇮🇷Hamedan University of Medical Sciences
- Maryam Sanatkar🇮🇷Hamedan University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Post-dural puncture headache (PDPH) is a common complication of spinal anesthesia. It often goes away after a few days but may be more severe in some patients and persists for weeks.
Objectives
This study aimed to evaluate the effect of oral magnesium on the prevention of PDPH after cesarean section for the first time.
Methods
In this double-blind, randomized clinical trial, 100 candidates for elective cesarean section under spinal anesthesia were randomly divided into 2 groups: (i) the intervention group that received 300 mg of oral magnesium powder and (ii) the control group that received starch powder. The frequency and severity of headache and amount of analgesic consumption in both groups were measured 1, 2, and 3 days after cesarean section. Data were analyzed using SPSS version 22 at 95% CI.
Results
The frequency of PDPH 1, 2, and 3 days after surgery was 8% vs 24% (P = 0.029), 10% vs 26% (P = 0.039), and 12% vs 18% (P = 0.401) in the intervention and control groups, respectively. The mean and SD of pain severity was 0.52 ± 1.83 vs 1.5 ± 2.84 (P = 0.03) on the first day, 0.70 ± 2.19 vs 1.58 ± 2.86 (P = 0.05) on the second day, and 0.82 ± 2.32 vs 1.18 ± 2.62 on the third day (P = 0.43) in the intervention and control groups, respectively. Although more patients in the control group received rescue analgesia, no significant difference was seen between the 2 study groups.
Conclusions
In women candidates for cesarean section, oral administration of 300 mg magnesium 2 hours before surgery significantly reduces the frequency and severity of PDPH, but its impact on reducing analgesic consumption is not significant.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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