Involvement of serotonergic neurotransmission in the antidepressant-like effect elicited by cholecalciferol in the chronic unpredictable stress model in mice
Neis VB, Werle I, Moretti M, Rosa PB, Camargo A, de O Dalsenter Y, Platt N, Rosado AF, Engel WD, de Almeida GRL, Selhorst I, Dafre AL, Rodrigues ALS
Metabolic brain disease · 7 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Animales
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Subvenciones
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (158126/2018-1); Conselho Nacional de Desenvolvimento Científico e Tecnológico (310113/2017-2); Conselho Nacional de Desenvolvimento Científico e Tecnológico (#421143/2018-5)
Según 1 financiador declarado.
Publicación
- Publicado
- 2022-04-18 · Metab Brain Dis · vol. 37 · número 5 · págs. 1597–1608
- Editorial
- Springer Science+Business Media
- Citado
- 9 citas · más que el 42% de estudios similares · 0.4× el promedio de su campo
- Referencias
- 58 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-SA
- Áreas de investigación
- Tryptophan and brain disorders · Stress Responses and Cortisol · Neuropeptides and Animal Physiology
- Palabras clave
- Serotonergic, Cholecalciferol, Antidepressant, Tail suspension test, Endocrinology, Fluoxetine, Internal medicine, Serotonin, Hippocampus, Behavioural despair test, Imipramine, Prefrontal cortex, Medicine, Pharmacology, Vitamin D and neurology, Psychiatry, Receptor, Pathology
- MeSH
- animals, humans, mice, serotonin, fluoxetine, cholecalciferol, antidepressive agents, hindlimb suspension, behavior, animal, depression, synaptic transmission, female
13 autores
- Vivian Binder Neis🇧🇷Universidade Federal de Santa Catarina
- Isabel Werle🇧🇷Universidade Federal de Santa Catarina
- Morgana Moretti🇧🇷Universidade Federal de Santa Catarina
- Priscila Batista da Rosa🇧🇷Universidade Federal de Santa Catarina
- Anderson Camargo🇧🇷Universidade Federal de Santa Catarina
- Yasmim de Oliveira Dalsenter🇧🇷Universidade Federal de Santa Catarina
- Nicolle Platt🇧🇷Universidade Federal de Santa Catarina
- Axel Fogaça Rosado🇧🇷Universidade Federal de Santa Catarina
- William D. Engel🇧🇷Universidade do Sul de Santa Catarina; Centro Universitário de Jaraguá do Sul; Universidade Sociedade Educacional de Santa Catarina
- Gudrian Ricardo Lopes de Almeida🇧🇷Universidade Federal de Santa Catarina
- Ingrid Selhorst🇧🇷Universidade Federal de Santa Catarina
- Alcir Luiz Dafré🇧🇷Universidade Federal de Santa Catarina
- Ana Lúcia S. Rodrigues🇧🇷 · autor de correspondenciaUniversidade Federal de Santa Catarina
Resumen
El texto original del estudio, en el idioma en que se publicó.
Cholecalciferol deficiency has been associated with stress-related psychiatric disorders, particularly depression. Therefore, the present study investigated the antidepressant-like effect of cholecalciferol in female mice and the possible role of the serotonergic system in this response. The ability of cholecalciferol to elicit an antidepressant-like effect and to modulate serotonin levels in the hippocampus and prefrontal cortex of mice subjected to chronic unpredictable stress (CUS) was also investigated. The administration of cholecalciferol (2.5, 7.5, and 25 µg/kg, p.o.) for 7 days, similar to fluoxetine (10 mg/kg, p.o., serotonin reuptake inhibitor), reduced the immobility time in the tail suspension test, without altering the locomotor performance in the open-field test. Moreover, the administration of p-chlorophenylalanine methyl ester (PCPA - 100 mg/kg, i.p., for 4 days, a selective inhibitor of tryptophan hydroxylase, involved in the serotonin synthesis) abolished the antidepressant-like effect of cholecalciferol and fluoxetine in the tail suspension test, demonstrating the involvement of serotonergic system. Additionally, CUS protocol (21 days) induced depressive-like behavior in the tail suspension test and decreased serotonin levels in the prefrontal cortex and hippocampus of mice. Conversely, the administration of cholecalciferol and fluoxetine in the last 7 days of CUS protocol completely abolished the stress-induced depressive-like phenotype. Cholecalciferol was also effective to abrogate CUS-induced reduction on serotonin levels in the prefrontal cortex, but not in the hippocampus. Our results indicate that cholecalciferol has an antidepressant-like effect in mice by modulating the serotonergic system and support the assumption that cholecalciferol may have beneficial effects for the management of depression.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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