Unveiling the effect of Withania somnifera on neuronal cytoarchitecture and synaptogenesis: A combined in vitro and network pharmacology approach
Mitra S, Munni YA, Dash R, Sultana A, Moon IS
Phytotherapy research : PTR · 11 citas
Etiquetas de revisión
Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio in vitro o de mecanismos (clasificado por nuestro filtro de IA)
- Estudiado en
- Células o muestras de laboratorio
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Korean Ministry of Science and ICT
Según 1 financiador declarado.
Publicación
- Publicado
- 2022-04-20 · Phytother Res · vol. 36 · número 6 · págs. 2524–2541
- Editorial
- Wiley
- Citado
- 14 citas · más que el 91% de estudios similares · 3.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 65 trabajos
- Acceso
- De pago
- Áreas de investigación
- Phytochemicals and Medicinal Plants · Medicinal Plants and Neuroprotection · Neuroscience and Neural Engineering
- Palabras clave
- Synaptogenesis, Neurotrophin, Withania somnifera, Pharmacology, Nerve growth factor, Tropomyosin receptor kinase A, Neuroscience, Hippocampal formation, Biology, Medicine, Receptor, Biochemistry
- MeSH
- neurons, humans, withania, memory disorders, nerve growth factor, plant extracts, molecular docking simulation, network pharmacology
5 autores
- Sarmistha Mitra🇰🇷Dongguk University
- Yeasmin Akter Munni🇰🇷Dongguk University
- Raju Dash🇰🇷Dongguk University
- Armin Sultana🇧🇩BGC Trust University Bangladesh
- Il Soo Moon🇰🇷 · autor de correspondenciaDongguk University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Withania somnifera (WS), is known for its remarkable contribution in herbal medicine and Ayurveda, which is therapeutically applied to improve memory and anxiety in patients. However, the pharmacological details of this plant on memory boosting yet remained undefined. This study provides mechanistic insights on the effect of ethanol solution extract of the whole plant of WS (WSEE) on neuritogenesis by combining in vitro and in silico network pharmacology approaches. WSEE promoted significant neuronal growth through early differentiation, axodendritic arborization, and synaptogenesis on primary hippocampal neurons. The network pharmacological study confirmed that the neuritogenic activity is potentially mediated by modulating the neurotrophin signaling pathway, where NRTK1 (TrkA) was revealed as the primary target of WS secondary metabolites. This neurotrophic activity of WSEE was significantly stifled by the presence of TrkA inhibitor, which further confirms the TrkA-dependent activity of WSEE. In addition, a molecular docking study suggested steroidal lactones present in the WS might act as nerve growth factor (NGF)-mimetics, activating TrkA by binding to the NGF-binding domain. As a whole, the findings of the study suggest a significant role of WSEE on neuritogenesis and its potential to function as a therapeutic agent and in drug designing for the prevention and treatment of memory-related neurological disorders.
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