Calorie Restriction with or without Time-Restricted Eating in Weight Loss
Liu D, Huang Y, Huang C, Yang S, Wei X, Zhang P, Guo D, Lin J, Xu B, Li C, He H, He J, Liu S, Shi L, Xue Y, Zhang H
The New England journal of medicine · 372 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Universidad u hospital
- Nanjing Agricultural University
- Universidad u hospital
- Southern Medical University
- Universidad u hospital
- Nanfang Hospital
- Gobierno
- National Key Research and Development Project of China
- Universidad u hospital
- Key-Area Clinical Research Program of Southern Medical University
- Gobierno
- Key-Area Research and Development Program of Guangdong Province
- Subvenciones
- Southern Medical University (2019B020227004); Southern Medical University (LC2019ZD010); National Natural Science Foundation of China (81970736); Southern Medical University (2018YFA0800404); National Natural Science Foundation of China (Nos.2018B030311031); National Natural Science Foundation of China (LC2019ZD010); Nanjing Agricultural University (No.2018YFA0800404); Southern Medical University (81970736)
Según 7 financiadores declarados.
Publicación
- Publicado
- 2022-04-20 · N Engl J Med · vol. 386 · número 16 · págs. 1495–1504
- Editorial
- Massachusetts Medical Society
- Citado
- 529 citas · más que el 100% de estudios similares · 49.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 27 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Dietary Effects on Health · Enhanced Recovery After Surgery · Circadian rhythm and melatonin
- Palabras clave
- Calorie restriction, Waist, Calorie, Body mass index, Medicine, Obesity, Weight loss, Circumference, Body weight, Low calorie diet, Demography, Internal medicine, Mathematics
- MeSH
- humans, obesity, weight loss, body mass index, caloric restriction, fasting, body composition, time factors, female, male
16 autores
- Deying Liu🇨🇳Nanfang Hospital; Southern Medical University
- Yan Huang🇨🇳Nanfang Hospital; Southern Medical University
- Chensihan Huang🇨🇳Nanfang Hospital; Southern Medical University
- Shunyu Yang🇨🇳Nanfang Hospital; Southern Medical University
- Xueyun Wei🇨🇳Nanfang Hospital; Southern Medical University
- Peizhen Zhang🇨🇳Nanfang Hospital; Southern Medical University
- Dan Guo🇨🇳Nanfang Hospital; Southern Medical University
- Jiayang Lin🇨🇳Nanfang Hospital; Southern Medical University
- Bingyan Xu🇨🇳Nanfang Hospital; Southern Medical University
- Changwei Li🇺🇸🇨🇳Tulane University; Southern Medical University
- Hua He🇺🇸🇨🇳Tulane University; Southern Medical University
- Jiang He🇺🇸🇨🇳Tulane University; Southern Medical University
- Shiqun Liu🇨🇳Nanfang Hospital; Southern Medical University
- Linna Shi🇨🇳Nanfang Hospital; Southern Medical University
- Yaoming Xue🇨🇳Nanfang Hospital; Southern Medical University
- Huijie Zhang🇨🇳Nanfang Hospital; Southern Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The long-term efficacy and safety of time-restricted eating for weight loss are not clear.
Methods
We randomly assigned 139 patients with obesity to time-restricted eating (eating only between 8:00 a.m. and 4:00 p.m.) with calorie restriction or daily calorie restriction alone. For 12 months, all the participants were instructed to follow a calorie-restricted diet that consisted of 1500 to 1800 kcal per day for men and 1200 to 1500 kcal per day for women. The primary outcome was the difference between the two groups in the change from baseline in body weight; secondary outcomes included changes in waist circumference, body-mass index (BMI), amount of body fat, and measures of metabolic risk factors.
Results
Of the total 139 participants who underwent randomization, 118 (84.9%) completed the 12-month follow-up visit. The mean weight loss from baseline at 12 months was -8.0 kg (95% confidence interval [CI], -9.6 to -6.4) in the time-restriction group and -6.3 kg (95% CI, -7.8 to -4.7) in the daily-calorie-restriction group. Changes in weight were not significantly different in the two groups at the 12-month assessment (net difference, -1.8 kg; 95% CI, -4.0 to 0.4; P = 0.11). Results of analyses of waist circumferences, BMI, body fat, body lean mass, blood pressure, and metabolic risk factors were consistent with the results of the primary outcome. In addition, there were no substantial differences between the groups in the numbers of adverse events.
Conclusions
Among patients with obesity, a regimen of time-restricted eating was not more beneficial with regard to reduction in body weight, body fat, or metabolic risk factors than daily calorie restriction. (Funded by the National Key Research and Development Project [No. 2018YFA0800404] and others; ClinicalTrials.gov number, NCT03745612.).
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