Preoperative oral magnesium loading to prevent postoperative atrial fibrillation following coronary surgery: a prospective randomized controlled trial
Tohme J, Sleilaty G, Jabbour K, Gergess A, Hayek G, Jebara V, Madi-Jebara S
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 8 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2022-04-19 · Eur J Cardiothorac Surg · vol. 62 · número 5
- Editorial
- Oxford University Press
- Citado
- 13 citas · más que el 65% de estudios similares · 0.8× el promedio de su campo
- Referencias
- 31 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Magnesium in Health and Disease · Atrial Fibrillation Management and Outcomes · Magnesium Alloys: Properties and Applications
- Palabras clave
- Medicine, Atrial fibrillation, Placebo, Randomization, Randomized controlled trial, Hypomagnesemia, Anesthesia, Cardiac surgery, Incidence (geometry), Surgery, Intensive care unit, Internal medicine, Magnesium
- MeSH
- humans, atrial fibrillation, postoperative complications, magnesium, coronary artery bypass, prospective studies
7 autores
- Joanna Tohme🇱🇧Saint Joseph University; Hôtel-Dieu de France
- Ghassan Sleilaty🇱🇧Saint Joseph University; Hôtel-Dieu de France
- Khalil Jabbour🇱🇧Saint Joseph University; Hôtel-Dieu de France
- Afrida Gergess🇱🇧Saint Joseph University; Hôtel-Dieu de France
- Gemma Hayek🇱🇧Saint Joseph University; Hôtel-Dieu de France
- Victor A. Jebara🇱🇧Saint Joseph University; Hôtel-Dieu de France
- Samia Madi‐Jebara🇱🇧Saint Joseph University; Hôtel-Dieu de France
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
Postoperative atrial fibrillation (POAF) is common following coronary artery bypass grafting (CABG) surgery. Hypomagnesemia is frequent after CABG surgery. No previous trials have assessed the effect of preoperative magnesium (Mg) loading on POAF incidence.
Methods
This was a single-centre, double-blind, placebo-controlled, parallel-group trial, with balanced randomization [1:1]. The participants were recruited from November 2018 until May 2019. Patients received either 3.2 g of Mg daily (4 tablets of 0.4 g each twice daily) for 72 h preoperatively and 1.6 g of Mg (4 tablets) on the day of surgery or placebo tablets.
Results
The primary outcome was the incidence of POAF. Secondary outcomes included time to extubation, transfusion rate, critical care unit and hospital length of stay. Of the 210 randomized participants, 200 (100 in each group) completed the study. A total of 10 (10%) and 22 (22%) subjects developed POAF in the Mg and placebo groups, respectively (RR = 0.45, 95% confidence interval: 0.23-0.91). Hospital and critical care unit length of stay were comparable between the 2 groups. No side effects related to Mg administration were documented.
Conclusions
In this randomized controlled trial, preoperative loading with oral administration of Mg for 3 days in patients admitted for CABG surgery decreases the incidence of POAF compared to placebo.
Clinical trial registration number
NCT03703349.
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