Blueberry Supplementation in Midlife for Dementia Risk Reduction
Krikorian R, Skelton MR, Summer SS, Shidler MD, Sullivan PG
Nutrients · 51 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- National Institute of Neurological Disorders and Stroke
- Gobierno
- NINDS NIH HHS
- Subvenciones
- National Institute of Neurological Disorders and Stroke (R21 NS111217)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-04-13 · Nutrients · vol. 14 · número 8 · pág. 1619
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 69 citas · más que el 95% de estudios similares · 4.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 99 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Neurological Disease Mechanisms and Treatments · Phytochemicals and Antioxidant Activities · Ginkgo biloba and Cashew Applications
- Palabras clave
- Cognitive decline, Dementia, Cognition, Medicine, Effects of sleep deprivation on cognitive performance, Overweight, Randomized controlled trial, Gerontology, Physiology, Internal medicine, Obesity, Psychiatry
- MeSH
- humans, dementia, risk reduction behavior, cognition, dietary supplements, middle aged, female, male, blueberry plants, cognitive dysfunction
5 autores
- Robert Krikorian🇺🇸 · autor de correspondenciaUniversity of Cincinnati Medical Center
- Matthew R. Skelton🇺🇸🇦🇺Cincinnati Children's Hospital Medical Center; Hospital Research Foundation
- Suzanne S. Summer🇺🇸Cincinnati Children's Hospital Medical Center
- Marcelle D. Shidler🇺🇸University of Cincinnati Medical Center
- Patrick G. Sullivan🇺🇸University of Kentucky
Resumen
El texto original del estudio, en el idioma en que se publicó.
Late-life dementia typically develops over a period of many years beginning in midlife. Prevalence of metabolic disturbance also accelerates in middle age and is a prominent risk factor for dementia. Preliminary studies indicate that blueberry supplementation can improve cognitive performance and influence metabolism and brain function and therefore may have a role in early intervention to prevent neurodegeneration. In a randomized controlled trial, we investigated the effects of daily blueberry supplementation in a middle-aged sample of insulin-resistant participants with elevated risk for future dementia. We enrolled overweight men and women, aged 50 to 65 years, with subjective cognitive decline (SCD) and performed pre- and post-intervention assessments of cognition and metabolism and exploratory measures of peripheral mitochondrial function. We observed improved performances for the blueberry group on measures of lexical access, p = 0.003, and memory interference, p = 0.04, and blueberry-treated participants reported reduced memory encoding difficulty in daily life activities, p = 0.03. The blueberry-treated group also exhibited correction of peripheral hyperinsulinemia, p = 0.04, and a modest trend for increased mitochondrial uncoupling, p = 0.11. The cognitive findings indicated improved executive ability in this middle-aged sample. In addition, the changes in metabolic and bioenergetic measures imply potential mechanistic factors associated with anthocyanin and proanthocyanidin actions. The demonstration of these benefits in middle-aged individuals with insulin resistance and SCD suggests that ongoing blueberry supplementation may contribute to protection against cognitive decline when implemented early in at-risk individuals.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.