Interactions between red and processed meat consumption and APOA5 gene variants associated with the incidence of metabolic syndrome in Korean adults
Choi WJ, Shin D
Genes & nutrition · 4 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoMezcla carne procesada con no procesadaSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Research Foundation
- Gobierno
- National Research Foundation of Korea
- Gobierno
- Ministry of Science and ICT, South Korea
- Gobierno
- Centers for Disease Control and Prevention
- Subvenciones
- National Research Foundation of Korea (2020R1G1A1004940)
Según 4 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-04-25 · Genes Nutr · vol. 17 · número 1 · pág. 5
- Editorial
- BioMed Central
- Citado
- 8 citas · más que el 81% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 39 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Nutritional Studies and Diet · Regulation of Appetite and Obesity · Genetic Associations and Epidemiology
- Palabras clave
- Red meat, Medicine, Metabolic syndrome, Obesity, Incidence (geometry), Diabetes mellitus, Genome-wide association study, Cohort, Minor allele frequency, Clinical nutrition, Internal medicine, Allele, Allele frequency, Genetics, Biology, Single-nucleotide polymorphism, Endocrinology, Gene, Genotype, Pathology
2 autores
- Woo Jeong Choi🇰🇷Inha University
- Dayeon Shin🇰🇷 · autor de correspondenciaInha University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Metabolic syndrome (MetS) is characterized by the coexistence of disorders such as diabetes, hypertension, hyperlipidemia, and obesity and is affected by genetic factors. Previous genome-wide association studies (GWAS) suggested that APOA5 gene variants were significantly associated with MetS and its components. Dietary factors such as red and processed meat consumption can cause chronic diseases, including hypertension, diabetes, and vascular depression. The aim of this study was to investigate the modulation of the incidence of MetS by the interaction between APOA5 rs662799 polymorphism and red and processed meat consumption.
Methods
In this prospective cohort study, 3266 participants were collected from the Korea Association REsource (KARE) cohort of the Korean Genome and Epidemiology Study (KoGES) from 2001 to 2016. APOA5 rs662799 polymorphism was extracted by GWAS using the Korean Chip. Red and processed meat consumption data were assessed using a semi-quantitative food frequency questionnaire.
Results
The incidence of MetS in carriers of the minor G allele of rs662799 (AG + GG) and the third tertile of red and processed meat consumption (serving/day) was higher than those with the major allele of rs662799 (AA) and the first tertile of red and processed meat consumption (HR 1.70, 95% CI 1.30-2.22, p interaction = 0.002).
Conclusions
An association between the presence of the minor alleles of rs662799 and high red and processed meat consumption and the incidence of MetS was observed in Korean adults.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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