Ultra-processed foods and risk of all-cause mortality in renal transplant recipients
Osté MCJ, Duan MJ, Gomes-Neto AW, Vinke PC, Carrero JJ, Avesani C, Cai Q, Dekker LH, Navis GJ, Bakker SJL, Corpeleijn E
The American journal of clinical nutrition · 34 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- European Commission
- Grupo de la industria
- Dutch Top Institute Food and Nutrition
- Gobierno
- European Union
- Subvenciones
- European Commission (A-1003); European Commission (HORIZON2020); European Commission (754425)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2022-02-26 · Am J Clin Nutr · vol. 115 · número 6 · págs. 1646–1657
- Editorial
- Elsevier BV
- Citado
- 43 citas · más que el 98% de estudios similares · 7.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 57 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Consumer Attitudes and Food Labeling · Dietary Effects on Health · Nutritional Studies and Diet
- Palabras clave
- Medicine, Cohort, Confounding, Food group, Proportional hazards model, Renal transplant, Food consumption, Internal medicine, Prospective cohort study, Transplantation, Environmental health
- MeSH
- kidney, humans, kidney transplantation, diet, prospective studies, energy intake, food handling, adult, aged, middle aged, female, male, fast foods
11 autores
- Maryse C.J. Osté🇳🇱 · autor de correspondenciaUniversity Medical Center Groningen; University of Groningen
- Ming-Jie Duan🇳🇱University Medical Center Groningen; University of Groningen
- Antonio W. Gomes Neto🇳🇱University Medical Center Groningen; University of Groningen
- Petra Corianne Vinke🇳🇱University Medical Center Groningen; University of Groningen
- Juan Jesús Carrero🇳🇱🇸🇪University Medical Center Groningen; University of Groningen; Karolinska Institutet
- Carla María Avesani🇳🇱🇸🇪University Medical Center Groningen; University of Groningen; Karolinska Institutet
- Qingqing Cai🇳🇱University Medical Center Groningen; University of Groningen
- Louise H. Dekker🇳🇱University Medical Center Groningen; University of Groningen
- Gerjan J Navis🇳🇱University Medical Center Groningen; University of Groningen
- Stephan J. L. Bakker🇳🇱University Medical Center Groningen; University of Groningen
- Eva Corpeleijn🇳🇱University Medical Center Groningen; University of Groningen
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Renal transplant recipients (RTRs) have a 6-fold higher risk of mortality than age- and sex-matched controls. Whether high consumption of ultra-processed foods is associated with survival in RTRs is unknown.
Objectives
We aimed to study the association between high consumption of ultra-processed foods and all-cause mortality in stable RTRs.
Methods
We conducted a prospective cohort study in adult RTRs with a stable graft. Dietary intake was assessed using a validated 177-item FFQ. Food items were categorized according to the NOVA classification system and the proportion ultra-processed foods comprised of total food weight per day was calculated.
Results
We included 632 stable RTRs (mean ± SD age: 53.0 ± 12.7 y, 57% men). Mean ± SD consumption of ultra-processed foods was 721 ± 341 g/d (28% of total weight of food intake), whereas the intake of unprocessed and minimally processed foods, processed culinary ingredients, and processed foods accounted for 57%, 1%, and 14%, respectively. During median follow-up of 5.4 y [IQR: 4.9-6.0 y], 129 (20%) RTRs died. In Cox regression analyses, ultra-processed foods were associated with all-cause mortality (HR per doubling of percentage of total weight: 2.13; 95% CI: 1.46, 3.10; P < 0.001), independently of potential confounders. This association was independent from the quality of the overall dietary pattern, expressed by the Mediterranean Diet Score (MDS) or Dietary Approaches to Stop Hypertension (DASH) score. When analyzing ultra-processed foods by groups, only sugar-sweetened beverages (HR: 1.21; 95% CI: 1.05, 1.39; P = 0.007), desserts (HR: 1.24; 95% CI: 1.02, 1.49; P = 0.03), and processed meats (HR: 1.87; 95% CI: 1.22, 2.86; P = 0.004) were associated with all-cause mortality.
Conclusions
Consumption of ultra-processed foods, in particular sugar-sweetened beverages, desserts, and processed meats, is associated with a higher risk of all-cause mortality after renal transplantation, independently of low adherence to high-quality dietary patterns, such as the Mediterranean diet and the DASH diet.This trial was registered at clinicaltrials.gov as NCT02811835.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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