A Presurgical-Window Intervention Trial of Isothiocyanate-Rich Broccoli Sprout Extract in Patients with Breast Cancer
Wang Z, Tu C, Pratt R, Khoury T, Qu J, Fahey JW, McCann SE, Zhang Y, Wu Y, Hutson AD, Ambrosone CB, Edge SB, Cappuccino HH, Takabe K, Young JS, Tang L
Molecular nutrition & food research · 19 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Cancer Institute
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Cancer Institute (K07 CA148888); National Cancer Institute (#P30 CA016056)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2022-04-27 · Mol Nutr Food Res · vol. 66 · número 12 · pág. e2101094
- Editorial
- Wiley
- Citado
- 25 citas · más que el 79% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 64 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Phytochemicals and Antioxidant Activities · Food Science and Nutritional Studies
- Palabras clave
- isothiocyanates, broccoli sprout extract, breast cancer, cruciferous vegetables, cleaved caspase-3, tumor-infiltrating lymphocytes, Ki-67, estrogen receptor alpha, urine proteomics, postmenopausal women
- MeSH
- humans, brassica, breast neoplasms, isothiocyanates, plant extracts, proteomics, female
16 autores
- Zinian Wang🇺🇸Roswell Park Comprehensive Cancer Center
- Chengjian Tu🇺🇸University at Buffalo, State University of New York
- Rachel N. Pratt🇺🇸Roswell Park Comprehensive Cancer Center
- Thaer Khoury🇺🇸Roswell Park Comprehensive Cancer Center
- Jun Qu🇺🇸University at Buffalo, State University of New York
- Jed W. Fahey🇺🇸Johns Hopkins University; George Mason University; Johns Hopkins Medicine
- Susan E. McCann🇺🇸Roswell Park Comprehensive Cancer Center
- Yuesheng Zhang🇺🇸Roswell Park Comprehensive Cancer Center
- Yue Wu🇺🇸Roswell Park Comprehensive Cancer Center
- Alan David Hutson🇺🇸Roswell Park Comprehensive Cancer Center
- Christine B. Ambrosone🇺🇸Roswell Park Comprehensive Cancer Center
- Stephen B. Edge🇺🇸Roswell Park Comprehensive Cancer Center
- Helen Cappuccino🇺🇸Roswell Park Comprehensive Cancer Center
- Kazuaki Takabe🇺🇸Roswell Park Comprehensive Cancer Center
- Jessica S. Young🇺🇸Roswell Park Comprehensive Cancer Center
- Li Tang🇺🇸 · autor de correspondenciaRoswell Park Comprehensive Cancer Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Scope
Dietary isothiocyanates (ITCs) from cruciferous vegetables have shown potent anti-breast cancer activities in preclinical models, but their anticancer effects in vivo in breast cancer patients remain elusive. A proof-of-principle, presurgical window of opportunity trial is conducted to assess the anticancer effects of dietary ITCs in breast cancer patients.
Methods and results
Thirty postmenopausal breast cancer patients are randomly assigned to receive ITC-rich broccoli sprout extract (BSE) (200 µmol ITC per day) or a placebo for 2 weeks. Expression of biomarkers related to ITCs functions are measured in breast cancer tissue specimens at pre- and post-interventions using immunohistochemistry staining. First morning urine samples are collected at both timepoints for proteomic analysis. Overall, the study shows high compliance (100%) and low toxicity (no grade 4 adverse event). Trends of increase in cleaved caspase 3 and tumor-infiltrating lymphocytes (TILs) and trends of decrease in Ki-67 and nuclear to cytoplasm ratio of estrogen receptor (ER)-α are observed in the BSE arm only, consistent with the significantly altered signaling pathways identified in urinary proteomic analysis.
Conclusions
Anticancer activities of ITCs are observed in breast cancer patients, supporting the potential beneficial roles of ITC-containing cruciferous vegetables in breast cancer prognosis.
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