Brain Photobiomodulation Improves Sleep Quality in Subjective Cognitive Decline: A Randomized, Sham-Controlled Study
Zhao X, Du W, Jiang J, Han Y
Journal of Alzheimer's disease : JAD · 17 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2022-04-29 · J Alzheimers Dis · vol. 87 · número 4 · págs. 1581–1589
- Editorial
- IOS Press
- Citado
- 22 citas · más que el 87% de estudios similares · 2.2× el promedio de su campo
- Referencias
- 59 trabajos
- Acceso
- De pago
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Transcranial Magnetic Stimulation Studies · Dementia and Cognitive Impairment Research
- Palabras clave
- low-level laser therapy
- MeSH
- brain, humans, alzheimer disease, cognition, cognitive dysfunction, sleep quality
4 autores
- Xing Zhao🇨🇳Capital Medical University; Xuan Wu Hospital of the Capital Medical University
- Wenying Du🇨🇳 · autor de correspondenciaCapital Medical University; Xuan Wu Hospital of the Capital Medical University
- Jiehui Jiang🇨🇳Shanghai University
- Ying Han🇨🇳 · autor de correspondenciaCapital Medical University; Hainan University; Xuan Wu Hospital of the Capital Medical University; Beijing Institute for Brain Disorders
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Sleep appears to be a sensitive biomarker that facilitates early detection and effective intervention for Alzheimer's disease, while subjective cognitive decline (SCD) is a risk factor for Alzheimer's disease. Prefrontal cortex atrophy is associated with both sleep disruption and cognitive decline. Transcranial brain photobiomodulation (PBM) therapy can enhance frontal cortex oxygen consumption, increasing frontal cortex mediated memory function.
Objective
This study aimed to test whether PBM therapy targeting the frontal cortex could improve sleep and cognitive function in SCD.
Methods
Fifty-eight SCDs were divided into the PBM group (N = 32) in which real light therapy was administered and a sham light therapy group (N = 26). All the participants received either real light or sham light therapy for 6 days consecutively, while the sleep data were recorded. The n-back task was employed to measure each participant's working memory.
Results
We found no differences in sleep efficiency change (F = 211, p = 0.279), REM stage percent change (F = 420, p = 0.91), and wake-up time (F = 212, p = 0.277) between the two groups. The sleep efficiency and REM were improved within the true light group on the fifth day. The true light group perform better than the control group in the n-back test, the accuracy was higher in the 2-back test (88.6% versus 79.6%, p = 0.001), and the reaction time in 1-back was shorter (544.80±202.00 versus 592.87±222.05, p = 0.003).
Conclusion
After five days of PBM therapy targeting the prefrontal cortex, sleep efficiency and N-back cognitive performance were improved on the fifth day.
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