25-hydroxyvitamin D is a predictor of COVID-19 severity of hospitalized patients
Nguyen NN, Raju MNP, da Graca B, Wang D, Mohamed NA, Mutnal MB, Rao A, Bennett M, Gokingco M, Pham H, Mohammad AA
PloS one · 10 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-05-03 · PLoS One · vol. 17 · número 5 · pág. e0268038
- Editorial
- Public Library of Science
- Citado
- 48 citas · más que el 98% de estudios similares · 6.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 21 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · COVID-19 Clinical Research Studies · Vitamin C and Antioxidants Research
- Palabras clave
- Medicine, Coronavirus disease 2019 (COVID-19), Vitamin D and neurology, Internal medicine, Logistic regression, Gastroenterology, Proportional hazards model, Odds ratio, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
- MeSH
- humans, calcifediol, 25-hydroxyvitamin d 2, vitamins, vitamin d, chromatography, liquid, tandem mass spectrometry, covid-19
11 autores
- Nguyen N. Nguyen🇺🇸 · autor de correspondenciaBaylor Scott & White Medical Center - Temple
- Muppala N. P. Raju🇺🇸Baylor Scott & White Medical Center - Temple
- Briget da Graca🇺🇸Baylor Scott & White Health; Baylor Scott & White Research Institute
- Dapeng Wang🇺🇸Baylor Scott & White Medical Center - Temple
- Nada Mohamed🇺🇸Baylor Scott & White Medical Center - Temple
- Manohar B. Mutnal🇺🇸Baylor Scott & White Medical Center - Temple
- Arundhati Rao🇺🇸Baylor Scott & White Medical Center - Temple
- Monica Bennett🇺🇸Baylor Scott & White Health; Baylor Scott & White Research Institute
- Matthew Gokingco🇺🇸Baylor Scott & White Medical Center - Temple
- Huy Nguyen Anh Pham🇺🇸Baylor Scott & White Medical Center - Temple
- Amin A. Mohammad🇺🇸Baylor Scott & White Medical Center - Temple
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
Studies investigating the association between vitamin D and severity of COVID-19 have mixed results perhaps due to immunoassay assessment of total 25-hydroxyvitamin D (tD) (the sum of 25-hydroxyvitamin-D2 [25-OH-D2] and 25-hydroxyvitamin-D3 [25-OH-D3]). Liquid chromatography tandem mass spectrometry (LC-MS/MS) has high analytical specificity and sensitivity for 25-OH-D2 and 25-OH-D3, and thus enables a more accurate assessment of impact on COVID-19 outcomes.
Methods
We established reference intervals for 25-OH-D3 and tD using LC-MS/MS. 25-OH-D2, 25-OH-D3 and tD were quantitated for 88 COVID-19 positive and 122 COVID-19 negative specimens. Chi-square or Fisher's exact tests were used to test associations in binary variables. T-Tests or Wilcoxon rank sum tests were used for continuous variables. Cox proportional hazards were used to test associations between 25-OH-D3 or tD levels and length of stay (LOS). For mortality and ventilation, logistic regression models were used.
Results
COVID-19 patients with deficient (<20 ng/mL) levels of 25-OH-D3 had significantly longer LOS by 15.3 days. COVID-19 P patients with deficient (<20 ng/mL) and insufficient (<30 ng/mL) of tD had significantly longer LOS by 12.1 and 8.2 days, respectively. Patients with insufficient levels of tD had significantly longer LOS by 13.7 days. COVID-19 patients with deficient serum 25-OH-D3 levels had significantly increased risk-adjusted odds of in-hospital mortality (OR [95% CI]: 5.29 [1.53-18.24]); those with insufficient 25-OH-D3 had significantly increased risk for requiring ventilation during hospitalization was found at LCMS insufficient cutoff (OR [95% CI]: 2.75 [1.10-6.90]).
Conclusions
There is an inverse relationship of 25-hydroxyvitamin D levels and hospital LOS for COVID-19 patients. Vitamin D status is a predictor for severity of outcomes. LCMS results are useful for assessing the odds of mortality and the need for ventilation during hospitalization.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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