Ageing modifies acute resting blood pressure responses to incremental consumption of dietary nitrate: a randomised, cross-over clinical trial
Capper T, Clifford T, Taylor G, Iqbal W, West D, Stevenson E, Siervo M
The British journal of nutrition · 7 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2022-05-04 · Br J Nutr · vol. 129 · número 3 · págs. 442–453
- Editorial
- Cambridge University Press
- Citado
- 10 citas · más que el 81% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 45 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY-NC-ND
- Áreas de investigación
- Cardiovascular Health and Disease Prevention · Nitric Oxide and Endothelin Effects · Blood Pressure and Hypertension Studies
- Palabras clave
- dietary nitrate, beetroot, blood pressure, aging, potassium nitrate, plasma nitrite, reactive hyperemia, nitric oxide, dose-response relationship, older adults, vascular function
- MeSH
- humans, beta vulgaris, vegetables, nitrates, nitrites, nitrogen dioxide, cross-over studies, aging, blood pressure, dietary supplements, adult, aged, middle aged, young adult
7 autores
- Tess Capper🇬🇧Queen's University Belfast; Newcastle University
- Tom Clifford🇬🇧Loughborough University; Newcastle University
- Guy Taylor🇬🇧Newcastle University
- Wasim Iqbal🇬🇧Newcastle University
- Daniel West🇬🇧Newcastle University
- Emma Stevenson🇬🇧Newcastle University
- Mario Siervo🇬🇧 · autor de correspondenciaUniversity of Nottingham; Queen's Medical Centre; Newcastle University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Beetroot (BR) is a rich source of nitrate (NO3-) that has been shown to reduce blood pressure (BP). Yet, no studies have examined the vascular benefits of BR in whole-food form and whether the effects are modified by age. This study was a four-arm, randomised, open-label, cross-over design in twenty-four healthy adults (young n 12, age 27 ± 4 years, old n 12, age 64 ± 5 years). Participants consumed whole-cooked BR at portions of (NO3- content in brackets) 100 g (272 mg), 200 g (544 mg) and 300 g (816 mg) and a 200-ml solution containing 1000 mg of potassium nitrate (KNO3) on four separate occasions over a 4-week period (≥7-d washout period). BP, plasma NO3- and nitrite (NO2-) concentrations, and post-occlusion reactive hyperaemia via laser Doppler, were measured pre- and up to 5-h post-intervention. Data were analysed by repeated-measures ANOVA. Plasma NO2- concentrations were higher in the young v. old at baseline and post-intervention (P 3- interventions decreased systolic and diastolic BP in young participants (P 3 (at 240-300 min post-intake) significantly decreased systolic (-4·8 mmHg, -3·5 %, P = 0·024) and diastolic (-5·4 mmHg, -6·5 %, P = 0·007) BP in older participants. In conclusion, incremental doses of dietary NO3- reduced systolic and diastolic BP in healthy young adults whereas in the older group a significant decrease was only observed with the highest dose. The lower plasma NO2- concentrations in older participants suggest that there may be mechanistic differences in the production of NO from dietary NO3- in young and older populations.
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