Financiado en parte por Almond Board of California
Almond Consumption for 8 Weeks Altered Host and Microbial Metabolism in Comparison to a Control Snack in Young Adults
Dhillon J, Newman JW, Fiehn O, Ortiz RM
Journal of the American Nutrition Association · 8 citas
Etiquetas de revisión
Alimentación controladaFinanciado por la industriaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- U.S. Department of Agriculture
- Grupo de la industria
- Almond Board of California
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute on Minority Health and Health Disparities
- Gobierno
- NIMHD NIH HHS
- Subvenciones
- U.S. Department of Agriculture (Project 2032-51530-025-00D); U.S. Department of Agriculture (2032‐51530‐025‐00D); National Institute on Minority Health and Health Disparities (K99 MD012815); National Institute on Minority Health and Health Disparities (R00MD012815)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2022-02-23 · J Am Nutr Assoc · vol. 42 · número 3 · págs. 242–254
- Editorial
- Taylor & Francis
- Citado
- 8 citas · más que el 72% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 76 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Nuts composition and effects · Gut microbiota and health · Nutritional Studies and Diet
- Palabras clave
- almond consumption, cardiometabolic health, serum metabolomics, gut microbiota metabolism, omega-3 fatty acids, tocopherols, TCA cycle, lysophosphatidylcholine, unsaturated phosphatidylcholine, oxylipins, endocannabinoids, amino sugar and nucleotide sugar metabolism, young adults
- MeSH
- humans, fatty acids, tocopherols, rna, ribosomal, 16s, adolescent, adult, gas chromatography-mass spectrometry, tandem mass spectrometry, young adult, snacks, prunus dulcis
4 autores
- Jaapna Dhillon🇺🇸 · autor de correspondenciaUniversity of California, Merced; University of Missouri
- John W. I. Newman🇺🇸Agricultural Research Service; United States Department of Agriculture; Western Human Nutrition Research Center; University of California, Davis
- Oliver Fiehn🇺🇸University of California, Davis
- Rudy Martin Ortiz🇺🇸University of California, Merced
Resumen
El texto original del estudio, en el idioma en que se publicó.
Almond consumption can improve cardiometabolic (CM) health. However, the mechanisms underlying those benefits are not well characterized. This study explored the effects of consuming a snack of almonds vs. crackers for 8 weeks on changes in metabolomic profiles in young adults (clinicaltrials.gov ID: NCT03084003).Participants (n = 73, age: 18-19 years, BMI: 18-41 kg/m2) were randomly assigned to consume either almonds (2 oz/d, n = 38) or an isocaloric control snack of graham crackers (325 kcal/d, n = 35) daily for 8 weeks. Blood samples were collected at baseline prior to and at 4 and 8 weeks after the intervention. Metabolite abundances in the serum were quantified by hydrophilic interaction chromatography quadrupole (Q) time-of-flight (TOF) mass spectrometry (MS/MS), gas chromatography (GC) TOF MS, CSH-ESI (electrospray) QTOF MS/MS, and targeted analyses for free PUFAs, total fatty acids, oxylipins and endocannabinoids. Linear mixed model analyses with baseline-adjustment were conducted, and those results were used for enrichment and network analyses. Microbial community pathway predictions from 16S rRNA sequencing of fecal samples was done using PICRUST2.Almond consumption enriched unsaturated triglycerides, unsaturated phosphatidylcholines, saturated and unsaturated lysophosphatidylcholines, tricarboxylic acids, and tocopherol clusters (p < 0.05). Targeted analyses reveal lower levels of omega-3 total fatty acids (TFAs) overall in the almond group compared to the cracker group (p < 0.05). Microbial amino acid biosynthesis, and amino sugar and nucleotide sugar metabolism pathways were also differentially enriched at the end of the intervention (p < 0.05).The study demonstrates the differential effects of almonds on host tocopherol, lipid, and TCA cycle metabolism with potential changes in microbial metabolism, which may interact with host metabolism to facilitate the CM benefits.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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