Association of Egg Consumption with Risk of All-Cause and Cardiovascular Disease Mortality: A Systematic Review and Dose-Response Meta-Analysis of Observational Studies
Ma W, Zhang Y, Pan L, Wang S, Xie K, Deng S, Wang R, Guo C, Qin P, Wu X, Wu Y, Zhao Y, Feng Y, Hu F
The Journal of nutrition · 8 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2022-05-05 · J Nutr · vol. 152 · número 10 · págs. 2227–2237
- Editorial
- Elsevier BV
- Citado
- 16 citas · más que el 60% de estudios similares · 0.8× el promedio de su campo
- Referencias
- 56 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nutritional Studies and Diet · Cardiovascular Health and Risk Factors · Lipoproteins and Cardiovascular Health
- Palabras clave
- egg consumption, all-cause mortality, cardiovascular mortality, ischemic heart disease mortality, stroke mortality, dose-response relationship, hyperlipidemia, older adults, dietary risk factors
- MeSH
- humans, cardiovascular diseases, myocardial ischemia, risk factors, databases, factual, aged, female, stroke
14 autores
- Wancheng Ma
- Yanyan Zhang
- Li Pan🇨🇳Shenzhen Luohu People's Hospital
- Sijia Wang
- Kui Xie
- Shan Deng
- Rui Wang
- Chunjiang Guo
- Pei Qin
- Xiaoyan Wu🇨🇳Shenzhen Chronic Disease Prevention Center
- Yuying Wu🇨🇳Shenzhen University; Shenzhen University Health Science Center
- Yang Zhao🇨🇳Shenzhen University; Shenzhen University Health Science Center
- Yifei Feng🇨🇳Shenzhen University; Shenzhen University Health Science Center
- Fulan Hu🇨🇳 · autor de correspondenciaShenzhen University; Shenzhen University Health Science Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Recent studies have reported conflicting associations between egg consumption and the risk of all-cause or cardiovascular disease (CVD) mortality, including ischemic heart disease (IHD) mortality and stroke mortality. With accumulating evidence, up-to-date evidence about the association should be synthesized.
Objectives
We aimed to assess the association of the risk of all-cause and CVD mortality with egg consumption.
Methods
We searched the PubMed, Embase, and Web of Science databases through 3 November, 2021 for observational studies conducted in participants ≥18 y of age and which provided ORs, RRs, or HRs and 95% CIs for ≥3 egg consumption categories or for increased intake of egg addressing the associations of interest. A random-effects model was used to pool the reported risk estimates. Restricted cubic splines were used to examine the dose-response association.
Results
Twenty-four articles with 48 reports (25 for all-cause mortality, 11 for CVD mortality, 6 for IHD mortality, and 6 for stroke mortality) involving 11,890,695 participants were included. Intake of each 1-egg/d increment was associated with increased risk of all-cause mortality (RR: 1.06; 95% CI: 1.02, 1.10; P = 0.008), but the association was restricted to women, Americans, and studies with adjustments for hyperlipidemia. Egg consumption was linearly associated with CVD mortality only in participants >60 y of age, Americans, studies with follow-up duration ≥15 y, and studies with adjustments for hyperlipidemia (P ≤ 0.018). No significant association was found between egg consumption and IHD or stroke mortality (P ≥ 0.080).
Conclusions
Egg consumption was linearly associated with a modestly increased risk of all-cause mortality and, in older participants, Americans, and studies with longer follow-up or adjustments for hyperlipidemia, CVD mortality. These findings suggest that it may be prudent to avoid high egg consumption.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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