Financiado en parte por Grain Foods Foundation
A randomized controlled trial of the effects of whole grains versus refined grains diets on the microbiome in pregnancy
Sun H, Yamada P, Paetow A, Chan M, Arslan A, Landberg R, Dominguez-Bello MG, Young BK
Scientific reports · 9 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- Grain Foods Foundation
Según 1 financiador declarado.
Publicación
- Publicado
- 2022-05-07 · Sci Rep · vol. 12 · número 1 · pág. 7509
- Editorial
- Nature Portfolio
- Citado
- 10 citas · más que el 65% de estudios similares · 0.7× el promedio de su campo
- Referencias
- 50 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Gut microbiota and health · Pelvic floor disorders treatments · Birth, Development, and Health
- Palabras clave
- Microbiome, Pregnancy, Gestation, Medicine, Lactobacillus, Obstetrics, Physiology, Obesity, Offspring, Gestational age, Biology, Animal science, Food science, Internal medicine, Bioinformatics
- MeSH
- humans, dietary carbohydrates, diet, pregnancy, infant, newborn, female, male, microbiota, whole grains, gestational weight gain
8 autores
- Haipeng Sun🇺🇸Rutgers, The State University of New Jersey
- Pamella Yamada🇺🇸NYU Langone Health
- Alexandra Paetow🇺🇸NYU Langone Health
- Michael C. W. Chan🇺🇸NYU Langone Health
- Alan A. Arslan🇺🇸NYU Langone Health
- Rikard Landberg🇸🇪Chalmers University of Technology
- Maria Gloria Domínguez-Bello🇺🇸Rutgers, The State University of New Jersey
- Bruce K. Young🇺🇸 · autor de correspondenciaNYU Langone Health
Resumen
El texto original del estudio, en el idioma en que se publicó.
Dietary whole grain consumption has been postulated to have metabolic benefits. The purpose of this study was to compare a pregnancy diet containing 75% of total carbohydrates as refined grains with a diet of 75% of total carbohydrates as whole grains for pregnancy outcomes and effects on the microbiome. Gestational weight gain, glucose tolerance and newborn outcomes were measured on 248 enrolled compliant women from whom a subset of 103 women consented to give 108 vaginal and 109 anal swabs. The data presented here are limited to the patients from whom the vaginal and anal swabs were obtained in order to study the microbiome. A microbiome-16SrRNA survey-was characterized in these samples. Samples and measurements were obtained at the first obstetrical visit, before beginning a prescribed diet (T1-baseline) and after 17-32 weeks on the prescribed diet (T3). Food frequency questionnaires and total plasma alkylresorcinols were used as a measure of whole grain consumption. There were no dietary differences in maternal weight gain, birth weight, or glucose tolerance test. Mothers consuming the whole grains diet showed a trend of gestational decrease in vaginal bacterial alpha diversity, with increasing Lactobacillus-dominance. No significant difference was observed for the anal microbiome. The results suggest that diet modulations of the vaginal microbiome during gestation may have important implications for maternal and neonatal health and in the intergenerational transfer of maternal microbiome. Trial registration: ClinicalTrials.gov Identifier: NCT03232762.
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