Time-Restricted Eating Regimen Differentially Affects Circulatory miRNA Expression in Older Overweight Adults
Saini SK, Singh A, Saini M, Gonzalez-Freire M, Leeuwenburgh C, Anton SD
Nutrients · 25 citas
Cómo se estudió
- Diseño
- Ensayo clínico controlado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Council of Scientific and Industrial Research, India
- Gobierno
- National Institutes of Health
- Gobierno
- Instituto de Salud Carlos III
- Gobierno
- National Institute on Aging
- Gobierno
- NIA NIH HHS
- Gobierno
- NIH HHS
- Subvenciones
- National Institute on Aging (P30 AG028740); National Institutes of Health (P30AG028740)
Según 6 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-04-28 · Nutrients · vol. 14 · número 9 · pág. 1843
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 30 citas · más que el 93% de estudios similares · 3.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 47 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Circadian rhythm and melatonin · Hydrogen's biological and therapeutic effects
- Palabras clave
- Overweight, microRNA, Regimen, Circulatory system, Young adult, Gerontology, Medicine, Physiology, Internal medicine, Psychology, Biology, Body mass index, Genetics, Gene
- MeSH
- humans, weight loss, micrornas, fasting, pilot projects, adult, aged, overweight
6 autores
- Sunil Kumar Saini🇺🇸🇮🇳University of Florida; Institute on Aging; All India Institute of Medical Sciences
- Arashdeep Singh🇺🇸University of Florida
- Manisha Saini
- Marta González‐Freire🇪🇸Health Research Institute of the Balearic Islands
- Christiaan Leeuwenburgh🇺🇸University of Florida; Institute on Aging
- Stephen Douglas Anton🇺🇸 · autor de correspondenciaUniversity of Florida Health; University of Florida; Institute on Aging
Resumen
El texto original del estudio, en el idioma en que se publicó.
Time-restricted eating (TRE), a popular form of intermittent fasting, has been demonstrated to provide multiple health benefits, including an extension of healthy lifespan in preclinical models. While the specific mechanisms remain elusive, emerging research indicates that one plausible mechanism through which TRE may confer health benefits is by influencing the expression of the epigenetic modulator circulatory miRNAs, which serve as intercellular communicators and are dysregulated in metabolic disorders, such as obesity. Therefore, the goal of this pilot study is to examine the effects of a 4-week TRE regimen on global circulatory miRNA from older (≥65 years) overweight participants. Pre- and post-TRE regimen serum samples from nine individuals who participated in the Time to Eat clinical trial (NCT03590847) and had a significant weight loss (2.6 kg, p < 0.01) were analyzed. The expressions of 2083 human miRNAs were quantified using HTG molecular whole transcriptome miRNA assay. In silico analyses were performed to determine the target genes and biological pathways associated with differentially expressed miRNAs to predict the metabolic effects of the TRE regimen. Fourteen miRNAs were differentially expressed pre- and post-TRE regimen. Specifically, downregulated miRNA targets suggested increased expression of transcripts, including PTEN, TSC1, and ULK1, and were related to cell growth and survival. Furthermore, the targets of downregulated miRNAs were associated with Ras signaling (cell growth and proliferation), mTOR signaling (cell growth and protein synthesis), insulin signaling (glucose uptake), and autophagy (cellular homeostasis and survival). In conclusion, the TRE regimen downregulated miRNA, which, in turn, could inhibit the pathways of cell growth and activate the pathways of cell survival and might promote healthy aging. Future mechanistic studies are required to understand the functional role of the miRNAs reported in this study.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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