Effects of Time-Restricted Feeding on Energy Balance: A Cross-Over Trial in Healthy Subjects
Bao R, Sun Y, Jiang Y, Ye L, Hong J, Wang W
Frontiers in endocrinology · 21 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Subvenciones
- National Natural Science Foundation of China (KY2019338)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-04-27 · Front Endocrinol (Lausanne) · vol. 13 · pág. 870054
- Editorial
- Frontiers Media
- Citado
- 23 citas · más que el 91% de estudios similares · 2.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 44 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Diet and metabolism studies · Circadian rhythm and melatonin
- Palabras clave
- Energy balance, Balance (ability), Time trial, Medicine, Animal science, Biology, Physical medicine and rehabilitation, Internal medicine, Ecology
- MeSH
- humans, fasting, cross-over studies, energy metabolism, energy intake, adult, female, young adult, healthy volunteers
6 autores
- Riqiang Bao🇨🇳Ruijin Hospital
- Yingkai Sun🇨🇳Ruijin Hospital
- Yiran Jiang🇨🇳Ruijin Hospital
- Lei Ye🇨🇳Ruijin Hospital
- Jie Hong🇨🇳 · autor de correspondenciaRuijin Hospital
- Weiqing Wang🇨🇳 · autor de correspondenciaRuijin Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Time-restricted feeding (TRF) has been recently reported as an effective dietary intervention for losing body weight, implying a negative energy balance, without restricting nutrient intake. However, the detailed energy balance alteration caused by TRF remains unclear. This study was a randomized controlled clinical trial using a within-subject cross-over design. Twelve healthy, normal-weighted volunteers (age: 24 ± 2.3 years; BMI: 21.9 ± 1.71 kg/m2; 7 females) were studied under a rigorous control for calorie intakes, physical activities as well as sleep-wake cycle to evaluate the energy balance systematically. Each participant consumed an isocaloric diet within either a 5.5-hour TRF or 11-hour control schedule. All energy intake and excretion were traced and collected and accessed by bomb calorimetry. Energy expenditure and substrates oxidation were monitored in a metabolic chamber. TRF compared with control schedule is associated with a 22.7% increase in fecal energy loss (Δ = 32.25 ± 9.33 Kcal, p = 0.005) and a trend in increasing 14.5% urine energy loss (Δ = 6.67 ± 3.14 Kcal, p = 0.058) without change energy expenditure. In total, a negative energy balance (Δ = -45.95 ± 19.00 Kcal, p = 0.034), which was equal to -2.6% of total energy intake, has been observed during TRF interventions. In the meantime, glycemic profiles, heart rate, respiration rate as well as metabolic flexibility were also improved during TRF intervention. Taken together, our findings unravel the mystery of how TRF regulates energy balance, supporting the use of TRF as an alternative dietary strategy for weight loss.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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