Positive Effects of Extra-Virgin Olive Oil Supplementation and DietBra on Inflammation and Glycemic Profiles in Adults With Type 2 Diabetes and Class II/III Obesity: A Randomized Clinical Trial
Silveira EA, Rosa LPS, de Resende DP, Rodrigues APDS, da Costa AC, Rezende ATO, Noll M, de Oliveira C, Junqueira-Kipnis AP
Frontiers in endocrinology · 7 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Gobierno
- Fundação de Amparo à Pesquisa do Estado de Goiás
- Gobierno
- Economic and Social Research Council
- Subvenciones
- Economic and Social Research Council (ES/T008822/1); Fundação de Amparo à Pesquisa do Estado de Goiás (201310267000003); Economic and Social Research Council (ES/T008822/1)
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-05-02 · Front Endocrinol (Lausanne) · vol. 13 · pág. 841971
- Editorial
- Frontiers Media
- Citado
- 12 citas · más que el 83% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 66 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Nutritional Studies and Diet · Adipokines, Inflammation, and Metabolic Diseases · Edible Oils Quality and Analysis
- Palabras clave
- extra virgin olive oil, type 2 diabetes, obesity, dietary supplementation, inflammation, inflammatory cytokines, interleukin-1 alpha, adiponectin, TNF-α, fasting insulin, glycemic control, body mass index, weight loss, Mediterranean diet, dietary intervention, insulin resistance, adipose tissue
- MeSH
- humans, diabetes mellitus, type 2, obesity, inflammation, insulin, blood glucose, dietary supplements, adult, adiponectin, biomarkers, olive oil
9 autores
- Érika Aparecida Silveira🇬🇧🇧🇷 · autor de correspondenciaUniversity College London; Universidade Federal de Goiás
- Lorena Pereira de Souza Rosa🇧🇷Instituto Federal de Goiás; Universidade Federal de Goiás
- Danilo Pires Resende🇧🇷Universidade Federal de Goiás
- Ana Paula dos Santos Rodrigues🇧🇷Universidade Federal de Goiás
- Adeliane Castro da Costa🇧🇷Universidade Federal de Goiás
- Andréa Toledo de Oliveira Rezende🇧🇷Universidade Federal de Goiás
- Mark A. Noll🇧🇷Instituto Federal Goiano; Instituto Federal de Goiás; Universidade Federal de Goiás
- Cesar Messias de Oliveira🇬🇧University College London
- Ana Paula Junqueira‐Kipnis🇧🇷Universidade Federal de Goiás
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Evidence on the effects of dietary interventions on inflammatory markers in individuals with obesity and type 2 diabetes mellitus (T2DM) is scarce. Our study evaluated the effects of extra-virgin olive oil alone and in combination with a traditional Brazilian diet on inflammatory markers and glycemic profiles in adults with both T2DM and class II/III obesity.
Methods
Adults aged 18-64 years with T2DM and class II/III obesity were randomized into two intervention groups: 1) extra-virgin olive oil only and 2) extra-virgin olive oil + a traditional Brazilian diet (OliveOil+DietBra). Data on sociodemographic characteristics, lifestyle, anthropometry, biochemical markers and inflammatory markers were collected. The primary outcomes were glycemic parameters and inflammatory markers. The body mass index (BMI) and weight were the secondary outcomes.
Results
Forty individuals with T2DM and class II/III obesity were enrolled, and 34 (85%) completed the intervention course. The intake of olive oil was 37.88 ± 12.50 mL/day in the olive oil group and 37.71 ± 12.23 mL/day in the OliveOil+DietBra group, with no significant difference between groups (p = 0.484). Compared to the olive oil only group, the OliveOil+DietBra group had significantly lower levels of fasting insulin (p = 0.047) at the end of the intervention, whereas the other glycemic parameters were not altered. In the OliveOil+DietBra group, serum levels of inflammatory cytokines, IL-1α (p = 0.006) and adiponectin (p = 0.049) were lower and those of TNFα were higher (p = 0.037). There was a significant reduction in BMI and weight compared to the baseline values in the OliveOil+DietBra group (p = 0.015).
Conclusions
The intervention with OliveOil+DietBra effectively decreased the levels of fasting insulin, IL-1α and adiponectin, suggesting its beneficial role in improving the inflammatory profiles and fasting insulin levels in adults with class II/III obesity and T2DM.
Clinical trial registration
ClinicalTrials.gov, identifier: NCT02463435.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.