Comparative randomized trial study about the efficacy of photobiomodulation and curcumin antimicrobial photodynamic therapy as a coadjuvant treatment of oral mucositis in oncologic patients: antimicrobial, analgesic, and degree alteration effect
de Cássia Dias Viana Andrade R, Azevedo Reis T, Rosa LP, de Oliveira Santos GP, da CristinaSilva F
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 21 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2022-05-24 · Support Care Cancer · vol. 30 · número 9 · págs. 7365–7371
- Editorial
- Springer Science+Business Media
- Citado
- 23 citas · más que el 92% de estudios similares · 2.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 24 trabajos
- Acceso
- De pago
- Áreas de investigación
- Oral health in cancer treatment · Oral Health Pathology and Treatment · Photodynamic Therapy Research Studies
- Palabras clave
- oral mucositis, low-level laser therapy, antimicrobial photodynamic therapy, curcumin, blue LEDs, Candida, chemotherapy-induced mucositis, radiotherapy-induced mucositis, analgesia, nystatin, photosensitizers
- MeSH
- humans, stomatitis, curcumin, analgesics, anti-infective agents, anti-bacterial agents, photochemotherapy, adolescent, mucositis
5 autores
- Rita de Cássia Dias Viana Andrade🇧🇷Universidade Cruzeiro do Sul
- Thaís Azevedo Reis🇧🇷 · autor de correspondenciaUniversidade Federal da Bahia
- Luciano Pereira Rosa🇧🇷Universidade Federal da Bahia
- Gabriel Pinto de Oliveira Santos🇧🇷Universidade Federal da Bahia
- Francine da CristinaSilva🇧🇷Universidade Federal da Bahia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
As conventional treatments currently available for mucositis are not considerably effective, there is a need to implement an adjuvant protocol for the treatment of oral mucositis in patients undergoing radiotherapy and chemotherapy.
Purpose
To evaluate the effect of photobiomodulation (PBM) and antimicrobial photodynamic therapy (aPDT) mediated by curcumin and blue LED as an adjunct treatment of oral mucositis for oncology patients using chemotherapy and/or radiotherapy.
Methods
Clinical, randomized study, in a single location, in an oncology service of a general hospital, with a total of 30 patients (over 18 years old) with stable oral mucosa lesions in the process of chemotherapy and/or radiotherapy. The patients were divided into 3 groups: control group (treated with nystatin), PBM group (treated with low-level laser therapy), and the aPDT group (treated with 450-nm blue LED and curcumin photosensitizer).
Results
The results showed, by means of intra-group comparisons, that the two experimental treatments promoted yeast reduction of the genus Candida in the last two evaluations (21 days and 30 days), but not in the first two evaluations (7 days and 14 days). The intra-group comparisons showed that the control and aPDT group showed a significant difference in the degree of mucositis over the four evaluations performed, with the results pointing out that the mucositis worsened in the control group from the 14th day, while reduced in the aPDT group from the 21st day of treatment.
Conclusion
A reduction in the degree of mucositis and pain score was observed in the PBM and aPDT groups, with the aPDT group standing out when presenting early clinical improvement in relation to the PBM group and the control group, thus emphasizing its effectiveness within the desired aspects. Regarding the antimicrobial effect, aPDT showed a greater reduction of yeasts of the genus Candida in the tested parameters.
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