High-density lipoprotein cholesterol efflux capacity and incidence of coronary artery disease and cardiovascular mortality: a systematic review and meta-analysis
Cheng W, Rosolowski M, Boettner J, Desch S, Jobs A, Thiele H, Buettner P
Lipids in health and disease · 15 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- China Scholarship Council
- Universidad u hospital
- Universitätsklinikum Leipzig
- Subvenciones
- China Scholarship Council (202009370095)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-05-28 · Lipids Health Dis · vol. 21 · número 1 · pág. 47
- Editorial
- BioMed Central
- Citado
- 16 citas · más que el 65% de estudios similares · 0.9× el promedio de su campo
- Referencias
- 67 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Cholesterol and Lipid Metabolism · Lipoproteins and Cardiovascular Health · Paraoxonase enzyme and polymorphisms
- Palabras clave
- cholesterol efflux capacity, HDL cholesterol, coronary artery disease, cardiovascular mortality, atherosclerosis, HDL function, dose-response relationship, cardiovascular risk
- MeSH
- animals, humans, incidence, odds ratio, risk factors, cholesterol, hdl, coronary artery disease
7 autores
- Wenke Cheng🇩🇪Leipzig Heart Institute; Leipzig University
- Maciej Rosołowski🇩🇪Leipzig University
- Julia Boettner🇩🇪Leipzig Heart Institute; Leipzig University
- Steffen Desch🇩🇪Leipzig Heart Institute; Leipzig University
- Alexander Jobs🇩🇪Leipzig Heart Institute; Leipzig University
- Hölger Thiele🇩🇪Leipzig Heart Institute; Leipzig University
- Petra G Buttner🇩🇪 · autor de correspondenciaLeipzig Heart Institute; University Hospital Leipzig; Leipzig University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The preventive effect of cholesterol efflux capacity (CEC) on the progression of atherosclerotic lesions has been confirmed in animal models, but findings in the population are inconsistent. Therefore, this meta-analysis aimed to systematically investigate the relationship of CEC with coronary artery disease (CAD) and cardiovascular mortality in a general population.
Methods
Four electronic databases (PubMed, Embase database, Cochrane Library, Web of Science) were searched from inception to February 1st, 2022 for relevant studies, without any language restriction. For continuous variables, the mean and standard deviation (SD), maximum adjusted odds ratios (ORs), relative risks (RRs), or hazard ratios (HRs) and 95% confidence intervals (CIs) were extracted. The random-effects model was adopted to calculate the pooled results, and dose-response analyses were conducted. All pooled results were expressed by standardized mean difference (SMD) and ORs.
Results
Finally, 18 observational studies were included. Compared with the non-CAD group, the CAD group (SMD -0.48, 95% CI - 0.66 to - 0.30; I2 88.9%) had significantly lower CEC. In the high-CEC population, the risks of CAD (OR 0.52, 95% CI 0.37 to 0.71; I2 81%) significantly decreased, and a linear negative dose-response was detected. However, an association between CEC and the risk of cardiovascular mortality was not found (OR 0.44, 95% CI 0.18 to 1.06; I2 83.2%).
Conclusions
This meta-analysis suggests that decreased CEC is strongly associated with the risk of CAD, independent of HDL-C level. However, a decreased CEC seems not to be related to cardiovascular mortality. Meanwhile, CEC is linearly negatively correlated with the risk of CAD.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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