Association of Dietary Magnesium Intake With Leukocyte Telomere Length in United States Middle-Aged and Elderly Adults
Hu L, Bai Y, Hu G, Zhang Y, Han X, Li J
Frontiers in nutrition · 8 citas
Cómo se estudió
- Diseño
- Estudio transversal (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Universidad u hospital
- Beihang University
- Universidad u hospital
- Peking University
- Gobierno
- National Key Research and Development Program of China
- Subvenciones
- National Natural Science Foundation of China (82003427); National Key Research and Development Program of China (2021YFC2500600); Beihang University (YWF-20-BJ-J-1053); National Natural Science Foundation of China (2021YFC2500600); National Key Research and Development Program of China (2021YFC2500601)
Según 4 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-05-19 · Front Nutr · vol. 9 · pág. 840804
- Editorial
- Frontiers Media
- Citado
- 9 citas · más que el 74% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 45 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Telomeres, Telomerase, and Senescence · Magnesium in Health and Disease · Genetics, Aging, and Longevity in Model Organisms
- Palabras clave
- Confounding, Medicine, National Health and Nutrition Examination Survey, Magnesium, Confidence interval, Telomere, Demography, Physiology, Internal medicine, Animal science, Environmental health, Biology, Population, Chemistry
6 autores
- Lihua Hu🇨🇳Peking University; Peking University First Hospital
- Yi Bai🇨🇳Peking University
- Guiping Hu🇨🇳 · autor de correspondenciaBeijing Advanced Sciences and Innovation Center; Beihang University
- Yan Zhang🇨🇳Peking University; Peking University First Hospital
- Xiaoning Han🇨🇳Peking University; Peking University First Hospital
- Jianping Li🇨🇳 · autor de correspondenciaPeking University; Peking University First Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aim
Magnesium supplementation may extend the life span; however, the biological mechanism is still unknown. Leukocyte telomere length (LTL) is a marker of cell aging and biological health in humans. Data concerning whether magnesium supplementation can maintain telomere length, thus prolonging life are limited. We aimed to investigate the association between dietary magnesium intake and LTL in United States middle-aged and elderly adults.
Methods
A total of 4,039 United States adults aged ≥ 45 years from National Health and Nutrition Examination Survey (1999-2002). Dietary magnesium intake was collected by a trained interviewer using 24-h dietary recall method and LTL was obtained using the quantitative polymerase chain reaction method. Multiple linear regression analysis was performed to evaluate the crude and adjusted association of dietary magnesium intake with LTL.
Results
The overall mean (SD) of LTL was 5.6 (0.6) kp. After adjusting potential confounders, every 1 mg increase in log-transformed dietary magnesium intake was associated with 0.20 kp (95% confidence intervals: 0.05-0.34) longer LTL. Participants with the highest tertile (≥299 mg) of dietary magnesium intake had statistically significant longer LTL (β = 0.07, P = 0.038) compared with the lowest tertile (P for interaction = 0.002). E-value analysis suggested robustness to unmeasured confounding.
Conclusion
Our findings showed that increased dietary magnesium intake was associated with longer LTL, which suggested that magnesium was conducive to a longer life expectancy.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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