The Potential Effect of Blueberry on Cognitive Health and Mood State based on Human Intervention Studies: Systematic Review and Mini Meta-Analysis
Soveid N, Barkhidarian B, Moradi S, Gholami F, Rasaei N, Himmerich H, Mirzaei K
CNS & neurological disorders drug targets · 8 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2022-06-09 · CNS Neurol Disord Drug Targets · vol. 22 · número 7 · págs. 1090–1101
- Editorial
- Bentham Science Publishers
- Citado
- 7 citas · más que el 28% de estudios similares · 0.3× el promedio de su campo
- Referencias
- 32 trabajos
- Acceso
- De pago
- Áreas de investigación
- Phytochemicals and Antioxidant Activities · Medicinal Plant Extracts Effects · Ginkgo biloba and Cashew Applications
- Palabras clave
- Meta-analysis, Mood, Medicine, Publication bias, Randomized controlled trial, Subgroup analysis, Random effects model, Forest plot, Systematic review, Cognition, MEDLINE, Clinical trial, Internal medicine, Clinical psychology, Psychiatry
- MeSH
- humans, cognition, reaction time, dietary supplements, blueberry plants
7 autores
- Neda Soveid🇮🇷Tehran University of Medical Sciences
- Bahareh Barkhidarian🇮🇷Tehran University of Medical Sciences
- Sajjad Moradi🇮🇷Kermanshah University of Medical Sciences; Niroo Research Institute
- Fatemeh Gholami🇮🇷Tehran University of Medical Sciences
- Niloufar Rasaei🇮🇷Tehran University of Medical Sciences
- Hubertus Himmerich🇬🇧King's College London
- Khadijeh Mirzaei🇮🇷 · autor de correspondenciaTehran University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Blueberries are known for their high content of several bioactive compounds, specifically anthocyanin, which are the most beneficial of the flavonoid family in terms of neuroprotection. Several human interventional studies have been conducted to assess the effects of blueberry intake on cognitive performance; however, the results of clinical trials are inconclusive. Therefore, this systematic review and meta-analysis evaluated the effect of blueberry supplementation on some aspects of cognitive performance and mood parameters using data from clinical trials based on existing evidence.
Methods
Relevant studies, published in April 2021, were searched through PubMed/Medline, Scopus, Embase, and Google Scholar. The random effect size was used to estimate the pooled effect size. Heterogeneity between studies was evaluated by the Cochrane Q test and I-squared (I2). To detect the potential source of heterogeneity, a subgroup analysis was conducted.
Results
Fourteenrandomized trials were included in the quantitative analysis, and six were pooled for statistical analysis. Blueberry intervention resulted in no significant change in mood state score (WMD = 0.03; 95% CI: -0.80 to 0.87, P = 0.16). Moreover, no significant effect of blueberry intake was shown in attention task reaction time (WMD = -1.50 ms; 95% CI: -24.75 to -21.75, P = 0.9), percentages of attention task accuracy (WMD = 0.85; 95% CI: -2.57 to 0.86, P = 0.3), one-back test accuracy (WMD = 0.03; 95% CI: -0.04 to 0.09, P = 0.4). Significant effect was indicated (WMD = 0.08; 95% CI: 0.02 to 0.13, P = 0.005) in two-back test accuracy.
Conclusion
We found a significant effect of blueberry consumption on two-back test accuracy as a cognitive outcome. More high-quality clinical trials according to the challenges mentioned seem to indicate the use of blueberry as a supplement for cognitive and mood health efficiently.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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