Dietary Magnesium Intake Level Modifies the Association Between Vitamin D and Insulin Resistance: A Large Cross-Sectional Analysis of American Adults
Liu Y, Gong R, Ma H, Chen S, Sun J, Qi J, Pang Y, An J, Su Z
Frontiers in nutrition · 7 citas
Cómo se estudió
- Diseño
- Estudio transversal (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Qinghai University
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-06-07 · Front Nutr · vol. 9 · pág. 878665
- Editorial
- Frontiers Media
- Citado
- 7 citas · más que el 63% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 45 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Vitamin D Research Studies · Adipokines, Inflammation, and Metabolic Diseases
- Palabras clave
- Insulin resistance, Medicine, Vitamin D and neurology, Internal medicine, Insulin, National Health and Nutrition Examination Survey, Vitamin, Cross-sectional study, Endocrinology, Magnesium, Population, Environmental health, Chemistry
9 autores
- Ya Liu🇨🇳Qinghai University
- Rongpeng Gong🇨🇳Qinghai University
- Haixiu Ma🇨🇳Qinghai University
- Siai Chen🇨🇳Qinghai University
- Jingwei Sun🇨🇳Qinghai University
- Jiarui Qi🇨🇳Qinghai University
- Yidan Pang🇨🇳Qinghai University
- Juan An🇨🇳 · autor de correspondenciaQinghai University
- Zhanhai Su🇨🇳Qinghai University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Previous clinical studies and randomized controlled trials have revealed that low serum vitamin D levels are associated with the risk of developing insulin resistance. Magnesium has been reported to be a protective factor for insulin resistance, and magnesium has been considered an important co-factor for vitamin D activation. However, the effect of dietary magnesium intake on the relationship between vitamin D and the risk of developing insulin resistance has not been comprehensively investigated. Therefore, we designed this cross-sectional analysis to assess whether dietary magnesium intake modifies the association of vitamin D and insulin resistance.
Methods
A total of 4,878 participants (male: 48.2%) from 4 consecutive cycles of the National Health and Nutrition Examination Survey (2007-2014) were included in this study after a rigorous screening process. Participants were stratified by their dietary magnesium intake into low-intake (<267 mg/day) and high-intake (≥267 mg/day) groups. We assessed differences between serum vitamin D levels and the risk of developing insulin resistance (interaction test), using a weighted multivariate logistic regression to analyze differences between participants with low and high magnesium intake levels.
Results
There was a negative association between vitamin D and insulin resistance in the US adult population [OR: 0.93 (0.88-0.98)], P P for interaction < 0.001). In the low dietary magnesium intake group, vitamin D was negatively associated with the insulin resistance [OR: 0.94 (0.90-0.98)]; in the high dietary magnesium intake group, vitamin D was negatively associated with insulin resistance [OR: 0.92 (0.88-0.96)].
Conclusion
Among adults in the United States, we found an independent association between vitamin D level and insulin resistance, and this association was modified according to different levels of magnesium intake.
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