Magnesium supplementation and insulin resistance in patients with rheumatoid arthritis
Norouzi M, Rezvankhah B, Haeri MR, Heydari H, Tafaroji J, Shafigh N, Avval JO, Dahmardeh AR, Masoumzadeh N, Gharehbeglou M
European journal of translational myology · 5 citas
Cómo se estudió
- Diseño
- Ensayo clínico controlado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-07-05 · Eur J Transl Myol · vol. 32 · número 3
- Editorial
- PAGEPress (Italy)
- Citado
- 8 citas · más que el 66% de estudios similares · 0.7× el promedio de su campo
- Referencias
- 35 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC
- Áreas de investigación
- Magnesium in Health and Disease · Medicinal plant effects and applications
- Palabras clave
- Medicine, Rheumatoid arthritis, Insulin resistance, Internal medicine, Insulin, Gastroenterology, Arthritis, Endocrinology, Homeostatic model assessment
10 autores
- Mohsen Norouzi🇮🇷 · autor de correspondenciaQom Islamic Azad University
- Boshra Rezvankhah🇮🇷 · autor de correspondenciaResearch Institute for Endocrine Sciences; Shahid Beheshti University
- Mohammad Reza Haeri🇮🇷 · autor de correspondenciaQom University of Medical Science and Health Services
- Hosein Heydari🇮🇷 · autor de correspondenciaQom University of Medical Science and Health Services
- Javad Tafaroji🇮🇷 · autor de correspondenciaUniversity of Qom; Qom University of Medical Science and Health Services
- Navid Shafigh🇮🇷 · autor de correspondenciaShahid Beheshti University; Shahid Beheshti University of Medical Sciences
- Jamshid Ordoni Avval🇮🇷 · autor de correspondenciaZahedan University of Medical Sciences
- Alireza Rahat Dahmardeh🇮🇷 · autor de correspondenciaZahedan University of Medical Sciences
- Niyoosha Masoumzadeh🇮🇷 · autor de correspondenciaUniversity of Tehran; Imam Khomeini Hospital; Zahedan University of Medical Sciences
- Mohammad Gharehbeglou🇮🇷 · autor de correspondenciaZahedan University of Medical Sciences; Shahid Beheshti University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Rheumatoid arthritis (RA) is a multifactorial disease affecting the immune system and many tissues in the body. This study aimed to evaluate the effect of magnesium supplementation on insulin resistance and fasting blood sugar (FBS) of patients with RA. In this prospective uncontrolled before-after study, RA patients referring to Rheumatology clinics of Qom City from January 2020 to January 2021 were evaluated. First, the patients received the routine rheumatoid arthritis treatment including 5 mg Prednisolone and 200mg Hydroxychloroquine daily for 6 months and FBS and insulin levels were measured after. Then, they received the routine arthritis rheumatoid treatment in addition to 300 mg/day oral Magnesium sulfate for 6 months and then, FBS and insulin levels were measured. The Homeostasis Model Assessment of insulin resistance (HOMA-IR) was used for determining insulin resistance. Thirty five patients with RA and the mean age of 49.83±2.58 years were enrolled. Twenty eight cases (80%) were female and 7 cases (20%) were male. The mean HOMA-IR before and after consumption of oral magnesium were 3.04±0.29 and 2.43±0.19, respectively. Statistically significant differences were found between FBS, insulin and HOMA-IR before and after consumption of oral magnesium (p<0.05). Our data suggested that magnesium supplementation reduces FBS, insulin and HOMA-IR in patients with rheumatoid arthritis. Thus, magnesium supplements may be an alternative method for prevention of type 2 diabetes in RA patients.
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