The effect of sesame oil consumption compared to sunflower oil on lipid profile, blood pressure, and anthropometric indices in women with non-alcoholic fatty liver disease: a randomized double-blind controlled trial
Vahedi H, Atefi M, Entezari MH, Hassanzadeh A
Trials · 9 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Isfahan University of Medical Sciences
- Subvenciones
- Isfahan University of Medical Sciences (399632); Isfahan University of Medical Sciences (IR.MUI.RESEARCH.REC.1399.548)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-07-08 · Trials · vol. 23 · número 1 · pág. 551
- Editorial
- Springer Science+Business Media
- Citado
- 20 citas · más que el 87% de estudios similares · 2.2× el promedio de su campo
- Referencias
- 56 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Sesame and Sesamin Research · Liver Disease Diagnosis and Treatment · Fatty Acid Research and Health
- Palabras clave
- non-alcoholic fatty liver disease, sesame oil, sunflower oil, dietary fat, lipid profile, blood pressure, anthropometric indices, weight loss, hypocaloric diet, women, dyslipidemia, TC/HDL-C ratio, systolic blood pressure, diastolic blood pressure, total cholesterol, HDL cholesterol, cardiovascular risk factors, Mediterranean diet, Mediterranean diet index, Mediterranean diet adherence
- MeSH
- humans, obesity, sesame oil, diet, reducing, double-blind method, blood pressure, iran, female, cholesterol, hdl, non-alcoholic fatty liver disease, sunflower oil
4 autores
- Hamid Vahedi🇮🇷Shahroud University of Medical Sciences
- Masoumeh Atefi🇮🇷Isfahan University of Medical Sciences
- Mohammad Hassan Entezari🇮🇷 · autor de correspondenciaIsfahan University of Medical Sciences
- Akbar Hassanzadeh🇮🇷Isfahan University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases in the world. There is strong evidence that dyslipidemia and other cardio-metabolic disorders are highly prevalent in patients with NAFLD. This trial aimed at examining the effect of sesame oil (SO) in the context of a weight loss program on lipid profile, blood pressure, and anthropometric indices in women with NAFLD.
Methods
This randomized, double-blind, controlled trial was carried out on 60 women with NAFLD. Subjects were randomly assigned to the SO group (n = 30) and sunflower oil (SFO) group (n = 30), each person consuming 30 g of oil per day for 12 weeks. All the participants received a hypocaloric diet (- 500 kcal/day) during the study. Lipid profile, blood pressure, and anthropometric indices were assessed at pre- and post-intervention phases.
Results
In total, 53 participants completed the study. Following 12 weeks of intervention, anthropometric indices (p 0.05). After adjusting for confounders, DBP (p = 0.031) and total cholesterol (TC) divided by high-density lipoprotein cholesterol (HDL-C) (p = 0.039) in the SO group were significantly reduced compared to the SFO group (p < 0.05).
Conclusions
The present clinical trial revealed that SO and SFO may not differently affect anthropometric indices, SBP, and lipid profile except for TC/HDL-C. In addition, SO may be effective in improvement of DBP and TC/HDL-C compared to the SFO group.
Trial registration
Ethical approval of this trial was obtained at Isfahan University of Medical Sciences with the reference number of IR.MUI.
Research
REC.1399.548 ( https://ethics.
Research
ac.ir/ProposalCertificateEn.php?id=158942&Print=true&NoPrintHeader=true&NoPrintFooter=true&NoPrintPageBorder=true&LetterPrint=true ), and it was registered before the start of the patient recruitment on December 12th, 2020 in the Iranian Registry of Clinical Trials (IRCT) with the registration number of IRCT20140208016529N6 .
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.