Financiado en parte por Danone
Whole grain germinated brown rice regulates intestinal immune homeostasis and gastrointestinal hormones in type 2 diabetic patients-a randomized control trial
Ding Q, Ren J, Zhou Y, Bai Z, Yan J, Na G, Shan Y
Food & function · 15 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Danone
- Gobierno
- Natural Science Foundation of Zhejiang Province
- Subvenciones
- Natural Science Foundation of Zhejiang Province (LY21H260004); Danone (DIC2016-05)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2022-01-01 · Food Funct · vol. 13 · número 15 · págs. 8274–8282
- Editorial
- Royal Society of Chemistry
- Citado
- 25 citas · más que el 92% de estudios similares · 3.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 20 trabajos
- Acceso
- De pago
- Áreas de investigación
- GABA and Rice Research · Gut microbiota and health · Nutrition, Genetics, and Disease
- Palabras clave
- Glycated hemoglobin, Bacteroides, Brown rice, Internal medicine, Type 2 diabetes, Immune system, Hormone, Type 2 Diabetes Mellitus, Glycemic, Feces, Food science, Resistin, Medicine, Endocrinology, Biology, Diabetes mellitus, Immunology, Insulin, Insulin resistance, Bacteria, Adipokine, Microbiology
- MeSH
- humans, diabetes mellitus, type 2, gastrointestinal hormones, blood glucose, homeostasis, aged, middle aged, oryza, whole grains
7 autores
- Qi Ding🇨🇳Wenzhou Medical University
- Junli Ren🇨🇳Harbin Institute of Technology
- Yingying Zhou🇨🇳Wenzhou Medical University
- Zhihuai Bai🇨🇳Wenzhou Medical University
- Jielin Yan🇨🇳Wenzhou Medical University
- Guanqiong Na🇨🇳Wenzhou Medical University
- Yujuan Shan🇨🇳Wenzhou Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background: Whole grains present distinguished benefits to a handful of metabolic syndromes (MetS). However, the preventive effects of germinated brown rice (GBR), a new type of brown rice, on patients with type 2 diabetes (T2DM) are rarely reported. Objectives: To investigate whether replacing 100 g refined white rice (RWR) with equal GBR per day is effective in T2DM and its underlying mechanisms. Methods: Ninety-nine qualified T2DM patients (64.58 ± 5.06 years old) were recruited. All patients were randomly divided into GBR group (100 g d-1 GBR for 12 weeks) and control group (keep the regular diet). Food frequency questionnaires, and fresh stool and serum samples were collected before and after the intervention, followed by various measurements. Results: Fasting blood glucose was obviously decreased after GBR intervention with an effective rate of 62%. Glycated hemoglobin (HbA1c) levels were decreased in the GBR group with no significance. In the GBR group, the abundance of beneficial bacteria in feces was increased, while harmful bacteria were decreased. The percentage of Bacteroides (57.2%) was largely increased. In addition, three types of short-chain fatty acids (SCFAs) including acetic acid, propanoic acid, and butyric acid were increased significantly by GBR (p p Conclusions: GBR (100 g d-1 for 12 weeks) has positive improvement in the fasting blood glucose for T2DM patients, which attributed to the recovery of intestinal homeostasis.
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