Time-restricted eating alters the 24-hour profile of adipose tissue transcriptome in men with obesity
Zhao L, Hutchison AT, Liu B, Wittert GA, Thompson CH, Nguyen L, Au J, Vincent A, Manoogian ENC, Le HD, Williams AE, Banks S, Panda S, Heilbronn LK
Obesity (Silver Spring, Md.) · 32 citas
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Vínculos de autores con la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo clínico controlado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Robert Wood Johnson Foundation
- Organización sin fines de lucro
- Diabetes Australia Research Trust
- Organización sin fines de lucro
- Diabetes Australia
- Universidad u hospital
- University of Adelaide
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIDDK NIH HHS
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK115214); Robert Wood Johnson Foundation (76014); Diabetes Australia Research Trust (Y18G‐HEIL); Robert Wood Johnson Foundation (DK118278); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK118278); National Institutes of Health (DK118278); National Institutes of Health (DK115214)
Según 7 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-08-01 · Obesity (Silver Spring) · vol. 31 · número S1 · págs. 63–74
- Editorial
- Wiley
- Citado
- 43 citas · más que el 96% de estudios similares · 4.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 54 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Dietary Effects on Health · Circadian rhythm and melatonin · Sleep and related disorders
- Palabras clave
- Endocrinology, Internal medicine, NEFA, PER1, Biology, Circadian rhythm, Adipose tissue, Hormone, Insulin, Circadian clock, Medicine, CLOCK
- MeSH
- adipose tissue, humans, obesity, melatonin, hydrocortisone, fatty acids, nonesterified, circadian rhythm, aged, middle aged, male, insulins, transcriptome, intermittent fasting
14 autores
- Lijun Zhao🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- Amy T. Hutchison🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- Bo Liu🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- Gary Wittert🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- Campbell Henry Thompson🇦🇺Royal Adelaide Hospital; The University of Adelaide
- Leanne Nguyen🇦🇺Royal Adelaide Hospital
- John Au🇦🇺Royal Adelaide Hospital
- Andrew D. Vincent🇦🇺The University of Adelaide
- Emily N. C. Manoogian🇺🇸Salk Institute for Biological Studies
- Hiep D. Le🇺🇸Salk Institute for Biological Studies
- April E. Williams🇺🇸Salk Institute for Biological Studies
- Siobhan Banks🇦🇺University of South Australia
- Satchidananda Panda🇺🇸Salk Institute for Biological Studies
- Leonie Kaye Heilbronn🇦🇺 · autor de correspondenciaSouth Australian Health and Medical Research Institute; The University of Adelaide
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Time-restricted eating (TRE) restores circadian rhythms in mice, but the evidence to support this in humans is limited. The objective of this study was to investigate the effects of TRE on 24-hour profiles of plasma metabolites, glucoregulatory hormones, and the subcutaneous adipose tissue (SAT) transcriptome in humans.
Methods
Men (n = 15, age = 63 [4] years, BMI 30.5 [2.4] kg/m2 ) were recruited. A 35-hour metabolic ward stay was conducted at baseline and after 8 weeks of 10-hour TRE. Assessment included 24-hour profiles of plasma glucose, nonesterified fatty acid (NEFA), triglyceride, glucoregulatory hormones, and the SAT transcriptome. Dim light melatonin onset and cortisol area under the curve were calculated.
Results
TRE did not alter dim light melatonin onset but reduced morning cortisol area under the curve. TRE altered 24-hour profiles of insulin, NEFA, triglyceride, and glucose-dependent insulinotropic peptide and increased transcripts of circadian locomotor output cycles protein kaput (CLOCK) and nuclear receptor subfamily 1 group D member 2 (NR1D2) and decreased period circadian regulator 1 (PER1) and nuclear receptor subfamily 1 group D member 1 (NR1D1) at 12:00 am. The rhythmicity of 450 genes was altered by TRE, which enriched in transcripts for transcription corepressor activity, DNA-binding transcription factor binding, regulation of chromatin organization, and small GTPase binding pathways. Weighted gene coexpression network analysis revealed eigengenes that were correlated with BMI, insulin, and NEFA.
Conclusions
TRE restored 24-hour profiles in hormones, metabolites, and genes controlling transcriptional regulation in SAT, which could underpin its metabolic health benefit.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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