Effect of preemptive photobiomodulation associated with nimesulide on the postsurgical outcomes, oxidative stress, and quality of life after third molar surgery: a randomized, split-mouth, controlled clinical trial
Cetira Filho EL, Silva PGB, Wong DVT, Choquenaira-Quispe C, Cesário FRAS, de Sousa Nogueira G, de Sousa AVC, de Aguiar ASW, da Cruz Fonseca SG, Costa FWG
Clinical oral investigations · 17 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Gobierno
- Ministério da Ciência, Tecnologia, Inovações e Comunicações
- Gobierno
- 427620/2018-0
- Subvenciones
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (2018-0); Ministério da Ciência, Tecnologia, Inovações e Comunicações (28/2018); Conselho Nacional de Desenvolvimento Científico e Tecnológico (#28/2018); Conselho Nacional de Desenvolvimento Científico e Tecnológico (MCTIC/CNPq No. 28/2018)
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-08-10 · Clin Oral Investig · vol. 26 · número 12 · págs. 6941–6960
- Editorial
- Springer Nature
- Citado
- 27 citas · más que el 90% de estudios similares · 2.5× el promedio de su campo
- Referencias
- 59 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Anesthesia and Pain Management · Dental Radiography and Imaging
- Palabras clave
- low-level laser therapy, nimesulide, third molar extraction, preemptive analgesia, postoperative pain, edema, trismus, oxidative stress, quality of life, glutathione, neutrophil migration
- MeSH
- mouth, molar, third, humans, tooth, impacted, trismus, pain, edema, sulfonamides, tooth extraction, double-blind method, oxidative stress, quality of life, low-level light therapy, postoperative pain
10 autores
- Edson Luiz Cetira Filho🇧🇷Universidade Federal do Ceará; Unichristus
- Paulo Goberlânio de Barros Silva🇧🇷 · autor de correspondenciaUnichristus
- Deysi Viviana Tenazoa Wong🇧🇷Universidade Federal do Ceará
- Celia Choquenaira-Quispe🇧🇷Universidade Federal do Ceará
- Francisco Rafael Alves Santana Cesário🇧🇷Universidade Federal do Ceará
- Gisele de Souza Nogueira🇧🇷Unichristus
- Alan Vieira Costa de Sousa🇧🇷Unichristus
- Andréa Sílvia Walter de Aguiar🇧🇷Universidade Federal do Ceará
- Said Gonçalves da Cruz Fonseca🇧🇷Universidade Federal do Ceará
- Fábio Wildson Gurgel Costa🇧🇷Universidade Federal do Ceará
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The aim of this study is to compare the effect of photobiomodulation with low-level laser therapy (LLLT) and nimesulide on inflammatory parameters, biomarkers of oxidative stress and inflammation, and quality of life after lower third molar (L3M) surgery.
Material and methods
A randomized, two-factor, triple-blind, controlled, split-mouth clinical trial was performed with 40 volunteers who required bilateral L3M removal. Patients were allocated depending on the use or not of 100 mg nimesulide 1 hbefore surgery, as well as the use or not of LLLT in the preoperative period.
Results
Pain peaks occurred after 6 h (nimesulide-placebo [N-P] group) and 8 h (nimesulide group). In the N-P group, LLLT resulted in significantly lower mean pain scores than the subgroup without LLLT after 4 h (p = 0.009) and 6 h (p = 0.048). As for edema, a shorter distance between the mandibular angle and the outer canthus of the eyes after 7 days (p = 0.037) and a smaller cumulative effect (p = 0.036) were observed in the N-P group associated with LLLT. A direct effect between LLLT (p = 0.047) and a reduction in the mean scores of overall dissatisfaction with quality of life was detected.
Conclusions
Preemptive use of nimesulide only delayed peak pain. LLLT reduced edema, trismus, and contributed to a better perception of quality of life. Nimesulide inhibits peroxidation by increasing GSH and stopping neutrophil migration. The benefit of the association of both strategies was not superior to the use of LLLT alone.
Clinical relevance
Translational study with impact on clinical-surgical protocols involving L3M surgery related to pharmacological and non-pharmacological methods.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.