Low-intensity red-light therapy in slowing myopic progression and the rebound effect after its cessation in Chinese children: a randomized controlled trial
Chen H, Wang W, Liao Y, Zhou W, Li Q, Wang J, Tang J, Pei Y, Wang X
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 94 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Xuzhou Medical University
- Universidad u hospital
- Development Fund Project of Affiliated Hospital of Xuzhou Medical University
- Gobierno
- Xuzhou Medical Leading Talent Training Project
Según 3 financiadores declarados.
Publicación
- Publicado
- 2022-08-17 · Graefes Arch Clin Exp Ophthalmol · vol. 261 · número 2 · págs. 575–584
- Editorial
- Springer Science+Business Media
- Citado
- 106 citas · más que el 99% de estudios similares · 13.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 39 trabajos
- Acceso
- De pago
- Áreas de investigación
- Ophthalmology and Visual Impairment Studies · Laser Applications in Dentistry and Medicine · Ocular and Laser Science Research
- Palabras clave
- myopia control, myopia progression, rebound effect, axial elongation, choroidal thickness, accommodative function, children, low-level laser therapy, refractive error, Chinese children, positive relative accommodation, accommodative response, spherical equivalent refraction, axial length
- MeSH
- humans, myopia, disease progression, refraction, ocular, phototherapy, prospective studies, child, axial length, eye, east asian people
9 autores
- Hongyan Chen🇨🇳Xuzhou Medical College
- Wei Wang🇨🇳Xuzhou Medical College
- Ya Liao🇨🇳Xuzhou Medical College
- Wen Jia Zhou🇨🇳Xuzhou Medical College
- Qin Li
- Jingjing Wang🇨🇳Xuzhou Medical College
- Jie Ting Tang🇨🇳Xuzhou Medical College
- Yifei Pei🇨🇳Xuzhou Medical College
- Xiaojuan Wang🇨🇳 · autor de correspondenciaXuzhou Medical College
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
To investigate the effect of low-intensity red-light (LRL) therapy on myopic control and the response after its cessation.
Methods
A prospective clinical trial. One hundred two children aged 6 to 13 with myopia were included in the LRL group (n = 51) and the single-focus spectacles (SFS) group (n = 51). In LRL group, subjects wore SFS and received LRL therapy provided by a laser device that emitted red-light of 635 nm and power of 0.35 ± 0.02 mW. One year after the control trial, LRL therapy was stopped for 3 months. The outcomes mainly included axial length (AL), spherical equivalent refraction (SER), subfoveal choroidal thickness (SFCT), and accommodative function.
Results
After 12 months of therapy, 46 children in the LRL group and 40 children in the SFS group completed the trial. AL elongation and myopic progression were 0.01 mm (95%CI: - 0.05 to 0.07 mm) and 0.05 D (95%CI: - 0 .08 to 0.19 D) in the LRL group, which were less than 0.39 mm (95%CI: 0.33 to 0.45 mm) and - 0.64 D (95%CI: - 0.78 to - 0.51 D) in the SFS group (p 0.05).
Conclusions
LRL is an effective measure for preventing and controlling myopia, and it may also have the ability to improve the accommodative function. There may be a slight myopic rebound after its cessation. The effect of long-term LRL therapy needs to be further explored.
Trial registration
Chinese Clinical Trial Registry: Chinese Clinical Trails registry: ChiCTR2100045250. Registered 9 April 2021; retrospectively registered. http://www.chictr.org.cn/showproj.aspx?proj=124250.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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