Effects of creatine supplementation on memory in healthy individuals: a systematic review and meta-analysis of randomized controlled trials
Prokopidis K, Giannos P, Triantafyllidis KK, Kechagias KS, Forbes SC, Candow DG
Nutrition reviews · 41 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2022-08-19 · Nutr Rev · vol. 81 · número 4 · págs. 416–427
- Editorial
- Oxford University Press
- Citado
- 71 citas · más que el 88% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 47 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Muscle metabolism and nutrition · Biochemical effects in animals · Nutrition and Health in Aging
- Palabras clave
- Creatine, Meta-analysis, Placebo, Randomized controlled trial, Medicine, Internal medicine, Strictly standardized mean difference, Cochrane Library, Physical therapy, Creatine kinase, Pathology, Alternative medicine
- MeSH
- humans, creatine, cognition, dietary supplements, aged, randomized controlled trials as topic
6 autores
- Konstantinos Prokopidis🇬🇧 · autor de correspondenciaUniversity of Liverpool
- Panagiotis Giannos🇬🇧Imperial College London
- Konstantinos Katsikas Triantafyllidis🇬🇧Musgrove Park Hospital; Taunton & Somerset NHS Foundation Trust; Somerset NHS Foundation Trust
- Konstantinos S. Kechagias🇬🇧Chelsea and Westminster Hospital NHS Foundation Trust; Imperial College London
- Scott C. Forbes🇨🇦Brandon University
- Darren Glenn Candow🇨🇦University of Regina
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
From an energy perspective, the brain is very metabolically demanding. It is well documented that creatine plays a key role in brain bioenergetics. There is some evidence that creatine supplementation can augment brain creatine stores, which could increase memory.
Objective
A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to determine the effects of creatine supplementation on memory performance in healthy humans.
Data sources
The literature was searched through the PubMed, Web of Science, Cochrane Library, and Scopus databases from inception until September 2021.
Data extraction
Twenty-three eligible RCTs were initially identified. Ten RCTs examining the effect of creatine supplementation compared with placebo on measures of memory in healthy individuals met the inclusion criteria for systematic review, 8 of which were included in the meta-analysis.
Data analysis
Overall, creatine supplementation improved measures of memory compared with placebo (standard mean difference [SMD] = 0.29, 95%CI, 0.04-0.53; I2 = 66%; P = 0.02). Subgroup analyses revealed a significant improvement in memory in older adults (66-76 years) (SMD = 0.88; 95%CI, 0.22-1.55; I2 = 83%; P = 0.009) compared with their younger counterparts (11-31 years) (SMD = 0.03; 95%CI, -0.14 to 0.20; I2 = 0%; P = 0.72). Creatine dose (≈ 2.2-20 g/d), duration of intervention (5 days to 24 weeks), sex, or geographical origin did not influence the findings.
Conclusion
Creatine supplementation enhanced measures of memory performance in healthy individuals, especially in older adults (66-76 years).
Systematic review registration
PROSPERO registration no. 42021281027.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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