Creatine Monohydrate Supplementation, but not Creatyl-L-Leucine, Increased Muscle Creatine Content in Healthy Young Adults: A Double-Blind Randomized Controlled Trial
Askow AT, Paulussen KJM, McKenna CF, Salvador AF, Scaroni SE, Hamann JS, Ulanov AV, Li Z, Paluska SA, Beaudry KM, De Lisio M, Burd NA
International journal of sport nutrition and exercise metabolism · 4 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
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- Financiación no declarada
Publicación
- Publicado
- 2022-08-25 · Int J Sport Nutr Exerc Metab · vol. 32 · número 6 · págs. 446–452
- Editorial
- Human Kinetics
- Citado
- 10 citas · más que el 67% de estudios similares · 0.9× el promedio de su campo
- Referencias
- 31 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Muscle metabolism and nutrition · Diet and metabolism studies · Obesity, Physical Activity, Diet
- Palabras clave
- Creatine Monohydrate, Creatine, Placebo, Medicine, Internal medicine, Randomized controlled trial, Endocrinology, Animal science, Physical therapy, Biology, Pathology
- MeSH
- muscle, skeletal, humans, amides, creatine, leucine, double-blind method, body composition, dietary supplements, female, male, muscle strength, leukemia, lymphocytic, chronic, b-cell, young adult
12 autores
- Andrew T. Askow🇺🇸University of Illinois Urbana-Champaign
- Kevin J.M. Paulussen🇺🇸University of Illinois Urbana-Champaign
- Colleen F. McKenna🇺🇸University of Illinois Urbana-Champaign
- Amadeo Félix Salvador🇺🇸University of Illinois Urbana-Champaign
- Susannah E. Scaroni🇺🇸University of Illinois Urbana-Champaign
- Jade S. Hamann🇺🇸University of Illinois Urbana-Champaign
- ALEXANDER V. ULANOV🇺🇸University of Illinois Urbana-Champaign
- Zhong Alan Li🇺🇸University of Illinois Urbana-Champaign
- Scott A. Paluska🇺🇸Methodist Sports Medicine
- Kayleigh M. Beaudry🇨🇦University of Ottawa
- Michael De Lisio🇨🇦University of Ottawa
- Nicholas A. Burd🇺🇸University of Illinois Urbana-Champaign
Resumen
El texto original del estudio, en el idioma en que se publicó.
Creatine (Cr) supplementation is a well-established strategy to enhance gains in strength, lean body mass, and power from a period of resistance training. However, the effectiveness of creatyl-L-leucine (CLL), a purported Cr amide, is unknown. Therefore, the purpose of this study was to assess the effects of CLL on muscle Cr content. Twenty-nine healthy men (n = 17) and women (n = 12) consumed 5 g/day of either Cr monohydrate (n = 8; 28.5 ± 7.3 years, 172.1 ± 11.0 cm, 76.6 ± 10.7 kg), CLL (n = 11; 29.2 ± 9.3 years, 170.3 ± 10.5 cm, 71.9 ± 14.5 kg), or placebo (n = 10; 30.3 ± 6.9 years, 167.8 ± 9.9 cm, 69.9 ± 11.1 kg) for 14 days in a randomized, double-blind design. Participants completed three bouts of supervised resistance exercise per week. Muscle biopsies were collected before and after the intervention for quantification of muscle Cr. Cr monohydrate supplementation which significantly increased muscle Cr content with 14 days of supplementation. No changes in muscle Cr were observed for the placebo or CLL groups. Cr monohydrate supplementation is an effective strategy to augment muscle Cr content while CLL is not.
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