Accumulation of Sulforaphane and Alliin in Human Prostate Tissue
Livingstone TL, Saha S, Bernuzzi F, Savva GM, Troncoso-Rey P, Traka MH, Mills RD, Ball RY, Mithen RF
Nutrients · 20 citas
Etiquetas de revisión
Alimentación controladaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Sin resultado de salud
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Prostate Cancer Foundation
- Gobierno
- UK Research and Innovation
- Universidad u hospital
- Quadram Institute Bioscience
- Gobierno
- Directorate for Biological Sciences
- Gobierno
- Biotechnology and Biological Sciences Research Council
- Gobierno
- UKRI Biotechnology and Biological Sciences Research Council through Institute Strategic Programme
- Gobierno
- BBSRC Core Capability
- Subvenciones
- Biotechnology and Biological Sciences Research Council (BB/RO12512/1 BB/CCG1860/1); Biotechnology and Biological Sciences Research Council (BB/CCG1860/1); UK Research and Innovation (BB/CCG1860/1); Biotechnology and Biological Sciences Research Council (1916087); Quadram Institute Bioscience (BB/CCG1860/1)
Según 7 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-08-10 · Nutrients · vol. 14 · número 16 · pág. 3263
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 31 citas · más que el 85% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 33 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Garlic and Onion Studies · Nutritional Studies and Diet
- Palabras clave
- sulforaphane, alliin, glucoraphanin, broccoli seeds, garlic, isothiocyanates, prostate tissue, prostate cancer chemoprevention, dietary supplements, cruciferous vegetables, prostate biopsy
- MeSH
- prostate, humans, brassica, allium, prostatic neoplasms, imidoesters, isothiocyanates, cysteine, sulfoxides, glucosinolates, antioxidants, male
9 autores
- Tracey L. Livingstone🇬🇧Norwich Research Park; Norfolk and Norwich University Hospital; Quadram Institute
- Shikha Saha🇬🇧Norwich Research Park; Quadram Institute
- Federico Bernuzzi🇬🇧Norwich Research Park; Quadram Institute
- George M. Savva🇬🇧Norwich Research Park; Quadram Institute
- Perla Troncoso‐Rey🇬🇧Norwich Research Park; Quadram Institute
- Μαρία Τράκα🇬🇧Norwich Research Park; Quadram Institute
- Robert Mills🇬🇧Norfolk and Norwich University Hospital
- Richard Y. Ball🇬🇧Norfolk and Norwich University Hospital
- Richard F. Mithen🇳🇿🇬🇧 · autor de correspondenciaUniversity of Auckland; Norwich Research Park; Quadram Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Diets rich in cruciferous vegetables have been associated with a lower risk of incidence and progression of prostate cancer. Sulforaphane, an isothiocyanate derived from 4-methylsulphinylbutyl glucosinolate (glucoraphanin) that accumulates in certain of these vegetables, notably broccoli, has been implicated in their protective effects. Likewise, the consumption of garlic and its sulphur-containing compounds such as alliin have been associated with a reduction in risk of prostate cancer. In this study, we tested whether consuming glucoraphanin derived from broccoli seeds and alliin derived from garlic resulted in the occurrence of these potential bioactive compounds in the prostate, which may contribute to our understanding of the putative protective effects of these dietary components. We recruited 42 men scheduled for a trans-perineal prostate biopsy into a randomised, double-blinded, 2 × 2-factorial dietary supplement four-week intervention study, and 39 completed the study. The two active interventions were supplements providing glucoraphanin from broccoli (BroccoMax®) and alliin from garlic (Kwai Heartcare®). Following the intervention, prostate biopsy tissue was analysed for the presence of sulforaphane and its thiol conjugates and for alliin and associated metabolites. Sulforaphane occurred in significantly higher levels in the prostate tissue (both within the transition and peripheral zone) of men consuming the glucoraphanin containing supplements (p < 0.0001) compared to men not consuming these supplements. However, while alliin and alliin-derived metabolites were detected within the prostate, there was no significant difference in the concentrations of these compounds in the prostate of men consuming supplements derived from garlic compared to men not consuming these supplements.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.