Financiado en parte por Saskatchewan Canola Development Commission, Canola Council of Canada, Alberta Canola Producers Commission, Manitoba Canola Growers Association, Canola Agri-Science Cluster, with funding provided by Agriculture and Agri-Food Canada, the Canola Council of Canada, Alberta Canola, SaskCanola, Dow Agro Sciences, and the Manitoba Canola Growers, Manitoba Canola Growers, SaskCanola, Dow Agro Sciences, Alberta Canola
Effects of Diets Enriched with Conventional or High-Oleic Canola Oils on Vascular Endothelial Function: A Sub-Study of the Canola Oil Multi-Centre Intervention Trial 2 (COMIT-2), a Randomized Crossover Controlled Feeding Study
Davis KM, Petersen KS, Bowen KJ, Jones PJH, Taylor CG, Zahradka P, Letourneau K, Perera D, Wilson A, Wagner PR, Kris-Etherton PM, West SG
Nutrients · 5 citas
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Alimentación controladaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- Saskatchewan Canola Development Commission
- Grupo de la industria
- Canola Council of Canada
- Grupo de la industria
- Alberta Canola Producers Commission
- Gobierno
- Agriculture and Agri-Food Canada
- Gobierno
- National Center for Advancing Translational Sciences
- Grupo de la industria
- Manitoba Canola Growers Association
- Grupo de la industria
- Canola Agri-Science Cluster, with funding provided by Agriculture and Agri-Food Canada, the Canola Council of Canada, Alberta Canola, SaskCanola, Dow Agro Sciences, and the Manitoba Canola Growers
- Gobierno
- NIH
- Gobierno
- NCATS NIH HHS
- Grupo de la industria
- Manitoba Canola Growers
- Grupo de la industria
- SaskCanola
- Empresa
- Dow Agro Sciences
- Grupo de la industria
- Alberta Canola
- Gobierno
- National Center for Advancing Translational Sciences, National Institutes of Health
- Subvenciones
- Saskatchewan Canola Development Commission (UL1 TR002014); Canola Council of Canada (UL1 TR002014); Alberta Canola Producers Commission (UL1 TR002014); National Center for Advancing Translational Sciences (UL 1 TR002014); Agriculture and Agri-Food Canada (UL1 TR002014); Manitoba Canola Growers Association (UL1 TR002014)
Según 14 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-08-18 · Nutrients · vol. 14 · número 16 · pág. 3404
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 10 citas · más que el 70% de estudios similares · 0.9× el promedio de su campo
- Referencias
- 59 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Cardiovascular Health and Disease Prevention · Nutritional Studies and Diet
- Palabras clave
- oleic acid, monounsaturated fatty acids, saturated fatty acids, flow-mediated dilation, endothelial function, brachial artery, cardiovascular risk, metabolic syndrome, dietary fatty acid composition, polyunsaturated fatty acids, waist circumference, brachial artery diameter
- MeSH
- humans, cardiovascular diseases, fatty acids, fatty acids, unsaturated, fatty acids, monounsaturated, oleic acid, diet, cross-over studies, metabolic syndrome, rapeseed oil
12 autores
- Kristin M. Davis🇺🇸Pennsylvania State University
- Kristina H. Petersen🇺🇸Texas Tech University; Pennsylvania State University
- Kate J. Bowen🇺🇸Pennsylvania State University
- Peter J.H. Jones🇨🇦University of Manitoba
- Carla G. Taylor🇨🇦St. Boniface Hospital; University of Manitoba
- Peter C. Zahradka🇨🇦St. Boniface Hospital; University of Manitoba
- Karen M. Letourneau🇨🇦St. Boniface Hospital
- Danielle Perera🇨🇦St. Boniface Hospital
- Angela Wilson🇨🇦St. Boniface Hospital
- Paul R. Wagner🇺🇸Pennsylvania State University
- Penny M. Kris‐Etherton🇺🇸 · autor de correspondenciaPennsylvania State University
- Sheila G. West🇺🇸Pennsylvania State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Partial replacement of saturated fatty acids (SFA) with unsaturated fatty acids is recommended to reduce cardiovascular disease (CVD) risk. Monounsaturated fatty acids (MUFA), including oleic acid, are associated with lower CVD risk. Measurement of flow-mediated dilation of the brachial artery (FMD) is the gold standard for measuring endothelial function and predicts CVD risk. This study examined the effect of partially replacing SFA with MUFA from conventional canola oil and high-oleic acid canola oil on FMD. Participants (n = 31) with an elevated waist circumference plus ≥1 additional metabolic syndrome criterion completed FMD measures as part of the Canola Oil Multi-Centre Intervention Trial 2 (COMIT-2), a multi-center, double-blind, three-period crossover, controlled feeding randomized trial. Diet periods were 6 weeks, separated by ≥4-week washouts. Experimental diets were provided during all feeding periods. Diets only differed by the fatty acid profile of the oils: canola oil (CO; 17.5% energy from MUFA, 9.2% polyunsaturated fatty acids (PUFA), 6.6% SFA), high-oleic acid canola oil (HOCO; 19.1% MUFA, 7.0% PUFA, 6.4% SFA), and a control oil blend (CON; 11% MUFA, 10% PUFA, 12% SFA). Multilevel models were used to examine the effect of the diets on FMD. No significant between-diet differences were observed for average brachial artery diameter (CO: 6.70 ± 0.15 mm, HOCO: 6.57 ± 0.15 mm, CON: 6.73 ± 0.14 mm; p = 0.72), peak brachial artery diameter (CO: 7.11 ± 0.15 mm, HOCO: 7.02 ± 0.15 mm, CON: 6.41 ± 0.48 mm; p = 0.80), or FMD (CO: 6.32 ± 0.51%, HOCO: 6.96 ± 0.49%, CON: 6.41 ± 0.48%; p = 0.81). Partial replacement of SFA with MUFA from CO and HOCO had no effect on FMD in participants with or at risk of metabolic syndrome.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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