Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? A systematic review and meta-analysis of randomized controlled trials
Akhgarjand C, Asoudeh F, Bagheri A, Kalantar Z, Vahabi Z, Shab-Bidar S, Rezvani H, Djafarian K
Phytotherapy research : PTR · 49 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2022-08-25 · Phytother Res · vol. 36 · número 11 · págs. 4115–4124
- Editorial
- Wiley
- Citado
- 74 citas · más que el 98% de estudios similares · 5.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 50 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY
- Áreas de investigación
- Phytochemicals and Medicinal Plants · Complementary and Alternative Medicine Studies · Medicinal Plants and Neuroprotection
- Palabras clave
- Medicine, Anxiety, Meta-analysis, Randomized controlled trial, Placebo, Strictly standardized mean difference, Confidence interval, Internal medicine, Clinical trial, Physical therapy, Traditional medicine, Alternative medicine, Psychiatry, Pathology
- MeSH
- humans, withania, plant extracts, anxiety, anxiety disorders, dietary supplements, adult, middle aged, randomized controlled trials as topic
8 autores
- Camellia Akhgarjand🇮🇷Tehran University of Medical Sciences
- Farzaneh Asoudeh🇮🇷Tehran University of Medical Sciences
- Amir Reza Bagheri🇮🇷Tehran University of Medical Sciences
- Zahra Kalantar🇮🇷Tehran University of Medical Sciences
- Zahra Vahabi🇮🇷Roozbeh Hospital; Tehran University of Medical Sciences
- Sakineh Shab‐Bidar🇮🇷Tehran University of Medical Sciences
- Hamid Reza Rezvani🇮🇷Taleghani General Hospital; Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
- Kurosh Djafarian🇮🇷 · autor de correspondenciaTehran University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Clinical trial studies revealed conflicting results on the effect of Ashwagandha extract on anxiety and stress. Therefore, we aimed to evaluate the effect of Ashwagandha supplementation on anxiety as well as stress. A systematic search was performed in PubMed/Medline, Scopus, and Google Scholar from inception until December 2021. We included randomized clinical trials (RCTs) that investigate the effect of Ashwagandha extract on anxiety and stress. The overall effect size was pooled by random-effects model and the standardized mean difference (SMD) and 95% confidence interval (CIs) for outcomes were applied. Overall, 12 eligible papers with a total sample size of 1,002 participants and age range between 25 and 48 years were included in the current systematic review and meta-analysis. We found that Ashwagandha supplementation significantly reduced anxiety (SMD: -1.55, 95% CI: -2.37, -0.74; p = .005; I2 = 93.8%) and stress level (SMD: -1.75; 95% CI: -2.29, -1.22; p = .005; I2 = 83.1%) compared to the placebo. Additionally, the non-linear dose-response analysis indicated a favorable effect of Ashwagandha supplementation on anxiety until 12,000 mg/d and stress at dose of 300-600 mg/d. Finally, we identified that the certainty of the evidence was low for both outcomes. The current systematic review and dose-response meta-analysis of RCTs revealed a beneficial effect in both stress and anxiety following Ashwagandha supplementation. However, further high-quality studies are needed to firmly establish the clinical efficacy of the plant.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.