Magnesium supplementation and iron status among female students: The intervention study
Milinković N, Zeković M, Dodevska M, Đorđević B, Radosavljević B, Ignjatović S, Ivanović N
Journal of medical biochemistry · 2 citas
Cómo se estudió
- Diseño
- Ensayo clínico controlado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
- Gobierno
- Ministry of Education, Science and Technological Development of the Republic of Serbia
- Subvenciones
- Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja (451-03-68/); Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja (175036); Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja (451–03-68/2020–14/200161); Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja (451-03-68 / 2020-14)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-12-23 · J Med Biochem · vol. 41 · número 3 · págs. 316–326
- Editorial
- De Gruyter
- Citado
- 4 citas · más que el 60% de estudios similares · 0.5× el promedio de su campo
- Referencias
- 44 trabajos
- Acceso
- Acceso abierto (publicación gratuita) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Iron Metabolism and Disorders · Potassium and Related Disorders
- Palabras clave
- Iron status, Intervention (counseling), Iron supplementation, Medicine, Psychology, Iron deficiency, Physiology, Gerontology, Internal medicine, Anemia, Nursing
7 autores
- Neda Milinković🇷🇸University of Belgrade
- Milica Zeković🇷🇸University of Belgrade; Centre of Research Excellence in Nutrition and Metabolism
- Margarita S. Dodevska🇷🇸Institute of Public Health of Serbia
- Brižita Đorđević🇷🇸University of Belgrade
- Branimir Radosavljević🇷🇸University of Belgrade
- Svetlana Ignjatović🇷🇸University of Belgrade
- Nevena Ivanović🇷🇸University of Belgrade
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Literature data indicate the benefit of magnesium (Mg) supplementation. The aim of this study was to examine the effect of short-term Mg supplementation on iron status in healthy female participants.
Methods
One hundred healthy female students of the University of Belgrade - Faculty of Pharmacy participated the study during eleven intervention days. Students ingested Mg preparations with the same dose of the active substance. The analysis included the measurement of serum iron, unsaturated iron binding capacity (UIBC), total iron binding capacity (TIBC), total Mg (tMg), ionized Mg (iMg), complete blood count, met-, carboxyand oxy-haemoglobin (metHgb, COHgb, O2Hgb). Transferrin concentrations and percentage of transferrin saturation (SAT) were calculated manually. The association among the analyzed biochemical parameters was examined using polynomial regression. A principal component analysis (PCA) was used for the evaluation of interdependence between the analyzed parameters.
Results
A statistically significant trend for change in O2Hgb (%) by tertiles of iMg concentrations was found (P = 0.029). Serum tMg reached significant positive correlation with the SAT at concentration levels greater than 0.9 mmol/L, after 11 days of intervention (R2=0.116). Ionized Mg in a concentration higher than 0.6 mmol/L is positively correlated with SAT and serum Fe (R2=0.214; 0.199, respectively). PCA revealed variability of 64.7% for two axes after 11 days.
Conclusions
Mg supplementation leads to an improvement in the certain iron status parameters even in individuals with optimal levels of these indices. However, caution should be exercised when supplementing Mg, and laboratory monitoring of the interaction is required.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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