The effects of coconut oil on the cardiometabolic profile: a systematic review and meta-analysis of randomized clinical trials
Duarte AC, Spiazzi BF, Zingano CP, Merello EN, Wayerbacher LF, Teixeira PP, Farenzena LP, de Araujo C, Amazarray CR, Colpani V, Gerchman F
Lipids in health and disease · 18 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Gobierno
- Ministério da Ciência, Tecnologia e Inovação
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Universidad u hospital
- Hospital de Clínicas de Porto Alegre
- Universidad u hospital
- Universidade Federal do Rio Grande do Sul
- Organización sin fines de lucro
- Fundação Instituto de Pesquisas Econômicas
- Universidad u hospital
- Pró-Reitoria de Pesquisa, Universidade Federal do Rio Grande do Sul
- Subvenciones
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq/MCTI/FNDCT18/2021 (420065/2021-0)); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq/MCTI/FNDCT18/2021); Hospital de Clínicas de Porto Alegre (FIPE-HCPA project 2018-0393)
Según 7 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-08-31 · Lipids Health Dis · vol. 21 · número 1 · pág. 83
- Editorial
- BioMed Central
- Citado
- 25 citas · más que el 23% de estudios similares · 0.2× el promedio de su campo
- Referencias
- 66 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Coconut Research and Applications · Diet and metabolism studies · Fatty Acid Research and Health
- Palabras clave
- coconut oil, saturated fatty acids, cardiometabolic profile, body weight, waist circumference, body fat percentage, LDL cholesterol, HDL cholesterol, triglycerides, glycemic response, insulin sensitivity, glycemic index, glycemic load, dietary fat intake, anthropometric outcomes, lipid profile, glycemic control, insulin resistance, dyslipidemia, type 2 diabetes
- MeSH
- humans, cardiovascular diseases, body weight, dietary fats, plant oils, adult, female, male, cholesterol, hdl, randomized controlled trials as topic, coconut oil
11 autores
- Ana Cláudia Duarte🇧🇷Universidade Federal do Rio Grande do Sul
- Bernardo Frison Spiazzi🇧🇷Universidade Federal do Rio Grande do Sul
- Carolina Pires Zingano🇧🇷Universidade Federal do Rio Grande do Sul; Hospital de Clínicas de Porto Alegre
- Eduarda Nunes Merello🇧🇷Universidade Federal do Rio Grande do Sul
- Laura Fink Wayerbacher🇧🇷Universidade Federal do Rio Grande do Sul
- Paula Portal Teixeira🇧🇷Universidade Federal do Rio Grande do Sul
- Laura Penso Farenzena🇧🇷Universidade Federal do Rio Grande do Sul
- Carina de Araújo🇧🇷Universidade Federal do Rio Grande do Sul
- Carmen Raya Amazarray🇧🇷Universidade Federal do Rio Grande do Sul
- Verônica Colpani🇧🇷Universidade Federal do Rio Grande do Sul; Hospital Moinhos de Vento
- Fernando Gerchman🇧🇷 · autor de correspondenciaUniversidade Federal do Rio Grande do Sul; Hospital Moinhos de Vento; Hospital de Clínicas de Porto Alegre
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Despite having a 92% concentration of saturated fatty acid composition, leading to an apparently unfavorable lipid profile, body weight and glycemic effect, coconut oil is consumed worldwide. Thus, we conducted an updated systematic review and meta-analysis of randomized clinical trials (RCTs) to analyze the effect of coconut oil intake on different cardiometabolic outcomes.
Methods
We searched Medline, Embase, and LILACS for RCTs conducted prior to April 2022. We included RCTs that compared effects of coconut oil intake with other substances on anthropometric and metabolic profiles in adults published in all languages, and excluded non-randomized trials and short follow-up studies. Risk of bias was assessed with the RoB 2 tool and certainty of evidence with GRADE. Where possible, we performed meta-analyses using a random-effects model.
Results
We included seven studies in the meta-analysis (n = 515; 50% females, follow up from 4 weeks to 2 years). The amount of coconut oil consumed varied and is expressed differently among studies: 12 to 30 ml of coconut oil/day (n = 5), as part of the amount of SFAs or total daily consumed fat (n = 1), a variation of 6 to 54.4 g/day (n = 5), or as part of the total caloric energy intake (15 to 21%) (n = 6). Coconut oil intake did not significantly decrease body weight (MD -0.24 kg, 95% CI -0.83 kg to 0.34 kg), waist circumference (MD -0.64 cm, 95% CI -1.69 cm to 0.41 cm), and % body fat (-0.10%, 95% CI -0.56% to 0.36%), low-density lipoprotein cholesterol (LDL-C) (MD -1.67 mg/dL, 95% CI -6.93 to 3.59 mg/dL), and triglyceride (TG) levels (MD -0.24 mg/dL, 95% CI -5.52 to 5.04 mg/dL). However, coconut oil intake was associated with a small increase in high-density lipoprotein cholesterol (HDL-C) (MD 3.28 mg/dL, 95% CI 0.66 to 5.90 mg/dL). Overall risk of bias was high, and certainty of evidence was very-low. Study limitations include the heterogeneity of intervention methods, in addition to small samples and short follow-ups, which undermine the effects of dietary intervention in metabolic parameters.
Conclusions
Coconut oil intake revealed no clinically relevant improvement in lipid profile and body composition compared to other oils/fats. Strategies to advise the public on the consumption of other oils, not coconut oil, due to proven cardiometabolic benefits should be implemented.
Registration
PROSPERO CRD42018081461.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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