Six-month intervention with wild blueberries improved speed of processing in mild cognitive decline: a double-blind, placebo-controlled, randomized clinical trial
Cheatham CL, Canipe LG, Millsap G, Stegall JM, Chai SC, Sheppard KW, Lila MA
Nutritional neuroscience · 24 citas
Etiquetas de revisión
Alimentación controladaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of North Carolina at Chapel Hill
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIDDK NIH HHS
- Universidad u hospital
- UNC-CH
- Sin clasificar
- monies
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK056350)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2022-09-06 · Nutr Neurosci · vol. 26 · número 10 · págs. 1019–1033
- Editorial
- Taylor & Francis
- Citado
- 32 citas · más que el 88% de estudios similares · 2.1× el promedio de su campo
- Referencias
- 38 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Phytochemicals and Antioxidant Activities · Dementia and Cognitive Impairment Research · Medicinal Plants and Neuroprotection
- Palabras clave
- Vaccinium angustifolium, flavonoids, mild cognitive decline, processing speed, cognitive aging, dietary intervention, event-related potentials, older adults, brain health
- MeSH
- humans, powders, double-blind method, cognition, quality of life, aged, blueberry plants, cognitive dysfunction
7 autores
- Carol L. Cheatham🇺🇸 · autor de correspondenciaUniversity of North Carolina at Chapel Hill
- L. Grant Canipe🇺🇸University of North Carolina at Chapel Hill; The Chicago School
- Grace Millsap🇺🇸University of North Carolina at Chapel Hill
- Julie M. Stegall🇺🇸University of North Carolina at Chapel Hill
- Sheau Ching Chai🇺🇸University of North Carolina at Chapel Hill; University of Delaware
- Kelly W. Sheppard🇺🇸University of North Carolina at Chapel Hill
- Mary Ann Lila🇺🇸North Carolina State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
As the sector of the population over 65y increases, cognitive decline and dementia become a public health issue. Interventions to improve brain health and thus, quality of life for older adults are needed.
Objective
It was hypothesized that those consuming a flavonoid-rich, lyophilized wild blueberry powder would evidence improvements in cognitive performance as measured behaviorally and electrophysiologically compared to those consuming a placebo powder across a 6-month intervention period.
Design
In a double-blind, randomized placebo-controlled trial, participants experiencing cognitive issues as determined by scores on the Montreal Cognitive Assessment (MoCA) were randomized to consume either wild blueberry (n = 44) or placebo (n = 42) powder daily for 6 months. Participants who were not experiencing any cognitive issues were included as a reference group (n = 45). Participants were tested at baseline and outcome on the Cambridge Neurological Test Automated Battery (CANTAB) and in an electrophysiological paradigm known as event-related potentials (ERP).
Results
Tests of specific cognitive abilities using the CANTAB showed speed of processing not only improved in the blueberry intervention group relative to the placebo group across the 6-month intervention, but blueberries also restored speed of processing to the level of the reference group. The ERP results also showed that, relative to those consuming placebo, speed of processing improved for those in the blueberry group; this improvement was most prominent in those 75-80y.
Conclusions
Consumption of wild blueberries for six months improves cognitive aging sequelae by improving the speed of information processing in older adults.Trial registration: ClinicalTrials.gov identifier: NCT01515098.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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