Clinical effectiveness of music interventions for dementia and depression in elderly care (MIDDEL): Australian cohort of an international pragmatic cluster-randomised controlled trial
Baker FA, Lee YC, Sousa TV, Stretton-Smith PA, Tamplin J, Sveinsdottir V, Geretsegger M, Wake JD, Assmus J, Gold C
The lancet. Healthy longevity · 50 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Medical Research Council
- Gobierno
- National Health and Medical Research Council
- Subvenciones
- National Health and Medical Research Council (1137853); Medical Research Council (MR/T046740/1)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2022-03-01 · Lancet Healthy Longev · vol. 3 · número 3 · págs. e153–e165
- Editorial
- Elsevier BV
- Citado
- 100 citas · más que el 100% de estudios similares · 18.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 27 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Music Therapy and Health · Dementia and Cognitive Impairment Research · Intensive Care Unit Cognitive Disorders
- Palabras clave
- Psychological intervention, Medicine, Randomized controlled trial, Dementia, Physical therapy, Cohort, Cluster randomised controlled trial, Observational study, Depression (economics), Singing, Clinical trial, Psychosocial, Anxiety, Psychiatry, Internal medicine
- MeSH
- humans, dementia, treatment outcome, music therapy, depression, communicable disease control, music, aged, australia, covid-19
10 autores
- Felicity Anne Baker🇦🇺🇳🇴 · autor de correspondenciaThe University of Melbourne; Norwegian Academy of Music
- Claire Lee🇦🇺The University of Melbourne
- Tanara Vieira Sousa🇦🇺The University of Melbourne
- Phoebe A Stretton-Smith🇦🇺The University of Melbourne
- Jeanette Tamplin🇦🇺The University of Melbourne
- Vigdis Sveinsdottir🇳🇴NORCE Research AS
- Monika Geretsegger🇳🇴NORCE Research AS
- Jo Dugstad Wake🇳🇴NORCE Research AS
- Jörg Aßmus🇳🇴NORCE Research AS
- Christian Gold🇦🇹🇳🇴University of Vienna; NORCE Research AS
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Dementia and depression are highly prevalent and comorbid conditions among older adults living in care homes and are associated with individual distress and rising societal costs. Effective, scalable, and feasible interventions are needed. Music interventions have shown promising effects, but the current evidence base is inconclusive. The present study aimed to determine the effectiveness of two different music interventions on the depressive symptoms of people with dementia living in residential aged care.
Methods
We implemented a 2 × 2 factorial cluster-randomised controlled trial to determine whether group music therapy (GMT) is more effective than no GMT with standard care, or recreational choir singing (RCS) is more effective than no RCS with standard care, for reducing depressive symptoms and other secondary outcomes in people with dementia with mild to severe depressive symptoms living in residential aged care. Care home units with at least ten residents were allocated to GMT, RCS, GMT plus RCS, or standard care, using a computer-generated list with block randomisation (block size four). The protocolised interventions were delivered by music therapists (GMT) and community musicians (RCS). The primary outcome was Montgomery-Åsberg Depression Rating Scale score at 6 months, assessed by a masked assessor and analysed on an intention-to-treat basis using linear mixed-effects models, which examined the effects of GMT versus no-GMT and RCS versus no-RCS, as well as interaction effects of GMT and RCS. We report on the Australian cohort of an international trial. This trial is registered with ClinicalTrials.gov, NCT03496675, and anzctr.org.au, ACTRN12618000156280.
Findings
Between June 15, 2018, and Feb 18, 2020, we approached 12 RAC facilities with 26 eligible care home units and, excluding six units who could not be enrolled due to COVID-19 lockdowns, we screened 818 residents. Between July 18, 2018, and Nov 26, 2019, 20 care home units were randomised (318 residents). Recruitment ceased on March 17, 2020, due to COVID-19. The primary endpoint, available from 20 care home units (214 residents), suggested beneficial effects of RCS (mean difference -4·25, 95% CI -7·89 to -0·62; p=0·0221) but not GMT (mean difference -0·44, -4·32 to 3·43; p=0·8224). No related serious adverse events occurred.
Interpretation
Our study supports implementing recreational choir singing as a clinically relevant therapeutic intervention in reducing depressive symptoms for people with dementia in the Australian care home context.
Funding
National Health and Medical Research Council, Australia.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.