Financiado en parte por Pfizer, GlaxoSmithKline, Novartis, Merck Research Laboratories and GlaxoSmithKline
Whole grain consumption and risk of radiographic knee osteoarthritis: a prospective study from the Osteoarthritis Initiative
Liu T, Xu C, Driban JB, Liang GY, Zhang XH, Hu FB, McAlindon T, Lu B
Rheumatology (Oxford, England) · 7 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoFinanciado por la industriaSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- U.S. Department of Health and Human Services
- Empresa
- Pfizer
- Empresa
- GlaxoSmithKline
- Empresa
- Novartis
- Universidad u hospital
- Tufts Medical Center
- Gobierno
- National Institutes of Health
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Gobierno
- NIAMS NIH HHS
- Empresa
- Merck Research Laboratories and GlaxoSmithKline
- Gobierno
- NIH
- Gobierno
- Department of Health and Human Services
- Gobierno
- NIH HHS
- Universidad u hospital
- Tupper Research Fund at Tufts Medical Center
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- U.S. Department of Health and Human Services (N01-AR-2-2258); U.S. Department of Health and Human Services (N01-AR-2-2261); National Institute of Arthritis and Musculoskeletal and Skin Diseases (N01 ‐ AR ‐ 2 ‐ 2261); U.S. Department of Health and Human Services (N01-AR-2-2262); National Institute of Arthritis and Musculoskeletal and Skin Diseases (N01‐AR‐2‐2260); National Institutes of Health (N01 AR‐2‐2260); National Institutes of Health (N01-AR-2-2258); National Institute of Arthritis and Musculoskeletal and Skin Diseases (N01-AR-2- 2262); National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 AR074447); National Heart, Lung, and Blood Institute (N01AR22258); U.S. Department of Health and Human Services (N01-AR-2-2259); National Institutes of Health (N01‐AR‐2‐2259); National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 AR074447 A1); U.S. Department of Health and Human Services (N01-AR-2-2260); National Institutes of Health (N01-AR-2-2261); National Institute of Arthritis and Musculoskeletal and Skin Diseases (N01AR22259); Pfizer (N01-AR-2-2262); GlaxoSmithKline (N01-AR-2-2262); National Institutes of Health (N01-AR-2-2262)
Según 15 financiadores declarados.
Publicación
- Publicado
- 2022-09-21 · Rheumatology (Oxford) · vol. 62 · número 5 · págs. 1834–1840
- Editorial
- Oxford University Press
- Citado
- 11 citas · más que el 84% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 50 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Nutritional Studies and Diet · Food composition and properties · Celiac Disease Research and Management
- Palabras clave
- Medicine, Osteoarthritis, Quartile, Hazard ratio, Prospective cohort study, Incidence (geometry), Internal medicine, Proportional hazards model, Confidence interval, Pathology
- MeSH
- knee joint, humans, osteoarthritis, knee, diet, risk factors, prospective studies, aged, middle aged, whole grains
8 autores
- Tong Liu🇺🇸🇨🇳Brigham and Women's Hospital; Harvard University; Lanzhou University
- Chang Qing Xu🇺🇸Rutgers, The State University of New Jersey; Brigham and Women's Hospital; Harvard University
- Jeffery B Driban🇺🇸Tufts Medical Center
- Geyu Liang🇨🇳Southeast University
- Xuehong Zhang🇺🇸Brigham and Women's Hospital; Harvard University
- Frank B. Hu🇺🇸Brigham and Women's Hospital; Harvard University
- Timothy E. McAlindon🇺🇸Tufts Medical Center
- Bing Lü🇺🇸 · autor de correspondenciaBrigham and Women's Hospital; Harvard University; Brown University; UConn Health
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
To assess the association of whole grain consumption with the risk of incident knee OA.
Material and methods
We followed 2846 participants in the Osteoarthritis Initiative ages 45-79 years. Participants were free from radiographic knee OA (Kellgren-Lawrence grade <2) in at least one knee at baseline. Dietary data from baseline were obtained using the Block Brief Food Frequency Questionnaire. We defined radiographic knee OA incidence as a Kellgren-Lawrence grade ≥2 during the subsequent 96 months. Cox proportional hazards models were used to assess the association between whole grain food intake and the risk of incident knee OA.
Results
During the 96 month follow-up, 518 participants (691 knees) developed incident radiographic knee OA. Higher total whole grain consumption was significantly associated with a lower knee OA risk [hazard ratio (HR)quartile 4vs1 = 0.66 (95% CI 0.52, 0.84), P for trend < 0.01] after adjusting for demographic and socio-economic factors, clinical factors and other dietary factors related to OA. Consistently, a significant inverse association of dark bread consumption with knee OA risk was observed [HRquartile 4vs1 = 0.68 (95% CI 0.53, 0.87), P for trend < 0.01). In addition, we observed a significant inverse association between higher cereal fibre intake and reduced knee OA risk [HRquartile 4vs1 = 0.61 (95% CI 0.46, 0.81), P for trend < 0.01).
Conclusions
Our findings revealed a significant inverse association of whole grain consumption with knee OA risk. These findings provide evidence that eating a diet rich in whole grains may be a potential nutritional strategy to prevent knee OA.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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