Blueberries and their bioactives in the modulation of oxidative stress, inflammation and cardio/vascular function markers: a systematic review of human intervention studies
Martini D, Marino M, Venturi S, Tucci M, Klimis-Zacas D, Riso P, Porrini M, Del Bo' C
The Journal of nutritional biochemistry · 37 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2022-09-20 · J Nutr Biochem · vol. 111 · pág. 109154
- Editorial
- Elsevier BV
- Citado
- 73 citas · más que el 97% de estudios similares · 3.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 117 trabajos
- Acceso
- De pago
- Áreas de investigación
- Phytochemicals and Antioxidant Activities · Antioxidant Activity and Oxidative Stress · Free Radicals and Antioxidants
- Palabras clave
- Oxidative stress, Inflammation, Intervention (counseling), Disease, Medicine, Bioinformatics, Physiology, Pharmacology, Immunology, Biology, Internal medicine
- MeSH
- animals, humans, fruit, cardiovascular diseases, inflammation, phenols, oxidative stress, biomarkers, blueberry plants
8 autores
- Daniela Martini🇮🇹University of Milan
- Mirko Marino🇮🇹University of Milan
- Samuele Venturi🇮🇹University of Milan
- Massimiliano Tucci🇮🇹University of Milan
- Dorothy J. Klimis‐Zacas🇺🇸University of Maine
- Patrizia Riso🇮🇹 · autor de correspondenciaUniversity of Milan
- Marisa Porrini🇮🇹University of Milan
- Cristian Del Bo’🇮🇹University of Milan
Resumen
El texto original del estudio, en el idioma en que se publicó.
Blueberries represent a rich source of (poly)phenols and other bioactive compounds. Numerous in vitro and animal model studies documented the potential health-promoting properties of blueberries and blueberry-bioactives, while little is still known about their effects in humans. The objective of the present systematic review is to provide main evidence and the potential mechanisms of action of blueberry and its (poly)phenols in the regulation of markers related to oxidative stress, inflammation, vascular and cardiometabolic function in health and disease states. A total of 45 human intervention studies were included in this review. Overall, the evidence suggests that blueberries may play a role in the improvement of markers of vascular function. Their effects were observed following both post-prandial and long-term consumption, particularly in subjects with risk factors and/or disease conditions. Conversely, the conflicting results on inflammation, oxidative stress and cardiometabolic risk markers were most likely due to differences among studies in terms of study design, subject characteristics, duration of intervention, dosage, and type of biomarkers analyzed. For these reasons, high-quality, well-designed, human intervention studies are warranted to strengthen the current findings on vascular function and provide more evidence about the impact of blueberries on the different markers considered. In addition, studies focusing on the relationship between the structure and the function of (poly)phenols will be fundamental for a better comprehension of the mechanisms behind the health effects observed.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.