Metabolic Efficacy of Time-Restricted Eating in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Liu L, Chen W, Wu D, Hu F
The Journal of clinical endocrinology and metabolism · 65 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- National Key Research and Development Program of China
- Gobierno
- National Nature Science Foundation of China
- Gobierno
- National Key R&D Program of China
- Subvenciones
- National Natural Science Foundation of China (31871180); National Key Research and Development Program of China (2020YFA0803604); National Natural Science Foundation of China (91957113)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2022-10-03 · J Clin Endocrinol Metab · vol. 107 · número 12 · págs. 3428–3441
- Editorial
- Oxford University Press
- Citado
- 81 citas · más que el 92% de estudios similares · 2.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 65 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dietary Effects on Health · Enhanced Recovery After Surgery · Genetics, Aging, and Longevity in Model Organisms
- Palabras clave
- Meta-analysis, Randomized controlled trial, Medicine, Psychology, Gerontology, Internal medicine
- MeSH
- humans, obesity, body weight, adult, overweight, cholesterol, ldl, randomized controlled trials as topic
4 autores
- Lili Liu🇨🇳Central South University; Second Xiangya Hospital of Central South University
- Wei Chen🇨🇳Central South University; Second Xiangya Hospital of Central South University
- Dan Wu🇨🇳Central South University; Second Xiangya Hospital of Central South University
- Fang Hu🇨🇳 · autor de correspondenciaCentral South University; Second Xiangya Hospital of Central South University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
Time-restricted eating (TRE), which restricts food intake to a limited duration of the day, is a key regimen of intermittent fasting.
Objective
The aim of our study was to provide an up-to-date meta-analysis and systematic review to evaluate the efficacy of TRE on weight loss and other metabolic-related parameters in adults.
Methods
We searched PubMed, EMBASE, and the Cochrane Library for relevant studies published before February 26, 2022. Study duration of TRE was at least 4 weeks. Body weight and other metabolic-related continuous parameters were described as weighted mean difference (WMD) with 95% CI.
Results
Seventeen randomized controlled trials involving 899 participants were analyzed. The pooled meta-analysis has shown that TRE contributed to a significant decrease in body weight with a WMD of -1.60 kg (95% CI -2.27 to -0.93) and fat mass with WMD -1.48 kg (95% CI -1.59 to -1.38). Subgroup analysis showed that TRE could reduce body weight and fat mass especially in overweight participants with WMD -1.43 kg (95% CI -2.05 to -0.81) and -1.56 kg (95% CI -1.67 to -1.44), respectively. TRE also showed beneficial effects on the lipid spectrum in overweight participants, including decreased levels of triglyceride (WMD -12.71 mg/dL, 95% CI -24.9 to -0.52), total cholesterol (WMD -6.45 mg/dL, 95% CI -7.40 to -5.49), and low-density lipoprotein cholesterol (WMD -7.0 mg/dL, 95% CI -9.74 to -4.25). However, compared with control, TRE had no significant effects on waist circumference, body mass index, glycosylated hemoglobin, or blood pressure.
Conclusion
This updated meta-analysis found that TRE may be an effective approach to improve the metabolic state of nonobese subjects, especially in overweight participants.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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