Financiado en parte por Novo Nordisk Fonden
Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial
Haganes KL, Silva CP, Eyjólfsdóttir SK, Steen S, Grindberg M, Lydersen S, Hawley JA, Moholdt T
Cell metabolism · 96 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Universidad u hospital
- Norges Teknisk-Naturvitenskapelige Universitet
- Organización sin fines de lucro
- European Foundation for the Study of Diabetes
- Gobierno
- Helse Midt-Norge
- Empresa
- Novo Nordisk Fonden
- Universidad u hospital
- Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet
- Subvenciones
- Novo Nordisk Fonden (NNF19SA0058975); Novo Nordisk Fonden (NNF19SA058975); Norges Teknisk-Naturvitenskapelige Universitet (NNF14OC0011493); Helse Midt-Norge (2020/39645)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2022-10-01 · Cell Metab · vol. 34 · número 10 · págs. 1457–1471.e4
- Editorial
- Cell Press
- Citado
- 137 citas · más que el 99% de estudios similares · 12.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 51 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Dietary Effects on Health · Circadian rhythm and melatonin · Diet and metabolism studies
- Palabras clave
- Medicine, Overweight, Glycemic, High-intensity interval training, Interval training, Randomized controlled trial, Obesity, Internal medicine, Glycemic load, Confidence interval, Physical therapy, Body mass index, Weight loss, Glycemic index, Insulin
- MeSH
- humans, cardiovascular diseases, obesity, glucose, exercise, body composition, female, overweight, glycated hemoglobin
8 autores
- Kamilla L. Haganes🇳🇴 · autor de correspondenciaNorwegian University of Science and Technology; St Olav's University Hospital
- Catalina P. Silva🇳🇴Norwegian University of Science and Technology
- Svala K. Eyjólfsdóttir🇳🇴Norwegian University of Science and Technology
- Sandra Steen🇳🇴Norwegian University of Science and Technology
- Martine Grindberg🇳🇴Norwegian University of Science and Technology
- Stian Lydersen🇳🇴Norwegian University of Science and Technology
- John A. Hawley🇦🇺Australian Catholic University
- Trine Tegdan Moholdt🇳🇴 · autor de correspondenciaNorwegian University of Science and Technology; St Olav's University Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Diet modification and exercise training are primary lifestyle strategies for obesity management, but poor adherence rates limit their effectiveness. Time-restricted eating (TRE) and high-intensity interval training (HIIT) improve cardiometabolic health in at-risk individuals, but whether these two interventions combined induce superior improvements in glycemic control than each individual intervention is not known. In this four-armed randomized controlled trial (ClinicalTrials.gov NCT04019860), we determined the isolated and combined effects of 7 weeks of TRE (≤10-h daily eating window, with ad libitum energy intake) and HIIT (three exercise sessions per week), compared with a non-intervention control group, on glycemic control and secondary cardiometabolic outcomes in 131 women (36.2 ± 6.2 years) with overweight/obesity. There were no statistically significant effects after isolated TRE, HIIT, or a combination (TREHIIT) on glucose area under the curve during an oral glucose tolerance test (the primary outcome) compared with the control group (TRE, -26.3 mmol/L; 95% confidence interval [CI], -82.3 to 29.7, p = 0.36; HIIT, -53.8 mmol/L; 95% CI, -109.2 to 1.6, p = 0.057; TREHIIT, -41.3 mmol/L; 95% CI, -96.4 to 13.8, p = 0.14). However, TREHIIT improved HbA1c and induced superior reductions in total and visceral fat mass compared with TRE and HIIT alone. High participant adherence rates suggest that TRE, HIIT, and a combination thereof may be realistic diet-exercise strategies for improving markers of metabolic health in women at risk of cardiometabolic disease.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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