Effect of time-restricted eating on sex hormone levels in premenopausal and postmenopausal females
Kalam F, Akasheh RT, Cienfuegos S, Ankireddy A, Gabel K, Ezpeleta M, Lin S, Tamatam CM, Reddy SP, Spring B, Khan SA, Varady KA
Obesity (Silver Spring, Md.) · 18 citas
Cómo se estudió
- Diseño
- Ensayo clínico controlado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NCI NIH HHS
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- National Cancer Institute (#T32CA193193); National Cancer Institute (R01CA257807); National Institute of Diabetes and Digestive and Kidney Diseases (R01DK119783); National Institutes of Health (R01 DK119783)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2022-10-06 · Obesity (Silver Spring) · vol. 31 · número S1 · págs. 57–62
- Editorial
- Wiley
- Citado
- 18 citas · más que el 86% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 29 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Dietary Effects on Health · Circadian rhythm and melatonin · Eating Disorders and Behaviors
- Palabras clave
- Androstenedione, Sex hormone-binding globulin, Internal medicine, Endocrinology, Estrone, Dehydroepiandrosterone, Medicine, Testosterone (patch), Hormone, Menopause, Estrogen, Postmenopausal women, Androgen
- MeSH
- humans, dehydroepiandrosterone, testosterone, estradiol, progesterone, gonadal steroid hormones, sex hormone-binding globulin, androgens, postmenopause, adult, female, intermittent fasting
12 autores
- Faiza Kalam🇺🇸Northwestern University
- Rand T. Akasheh🇯🇴🇺🇸American University of Madaba; University of Illinois Chicago
- Sofia Cienfuegos🇺🇸University of Illinois Chicago
- Aparna Ankireddy🇺🇸University of Illinois Chicago
- Kelsey Gabel🇺🇸University of Illinois Chicago
- Mark Ezpeleta🇺🇸University of Illinois Chicago
- Shuhao Lin🇺🇸University of Illinois Chicago
- Chandra Mohan Tamatam🇺🇸University of Illinois Chicago
- Sekhar P. Reddy🇺🇸University of Illinois Chicago
- Bonnie J. Spring🇺🇸Northwestern University
- Seema Ahsan Khan🇺🇸Northwestern University
- Krista A Varady🇺🇸 · autor de correspondenciaUniversity of Illinois Chicago
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Concerns have been raised regarding the impact of time-restricted eating (TRE) on sex hormones in females. This study examined how TRE affects sex steroids in premenopausal and postmenopausal females.
Methods
This is a secondary analysis of an 8-week TRE study (4- to 6-hour eating window) conducted in adults with obesity. Men and perimenopausal females were excluded. Females were classified into two groups based on menstrual status: premenopausal (n = 12) or postmenopausal (n = 11).
Results
After 8 weeks, body weight decreased in premenopausal females (-3% ± 2%) and postmenopausal females (-4% ± 2%) (main effect of time, p < 0.001), with no difference between groups (no group × time interaction). Circulating levels of testosterone, androstenedione, and sex hormone binding globulin (SHBG) did not change in either group (no group × time interaction). Dehydroepiandrosterone (DHEA) concentrations decreased (p < 0.05) in premenopausal (-14% ± 32%) and postmenopausal females (-13% ± 34%; main effect of time, p = 0.03), with no difference between groups. Estradiol, estrone, and progesterone were measured only in postmenopausal females, and they remained unchanged.
Conclusions
In premenopausal females, androgens and SHBG remained unchanged during TRE, whereas DHEA decreased. In postmenopausal females, estrogens, progesterone, androgens, and SHBG did not change, but DHEA was reduced.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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