Time-restricted eating with or without low-carbohydrate diet reduces visceral fat and improves metabolic syndrome: A randomized trial
He M, Wang J, Liang Q, Li M, Guo H, Wang Y, Deji C, Sui J, Wang YW, Liu Y, Zheng Y, Qian B, Chen H, Ma M, Su S, Geng H, Zhou WX, Guo X, Zhu WZ, Zhang M, Chen Z, Rensen PCN, Hui CC, Wang Y, Shi B
Cell reports. Medicine · 73 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Xi’an Jiaotong University
- Gobierno
- National Key Research and Development Program of China
- Subvenciones
- National Key Research and Development Program of China (2018YFC1311501)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-10-01 · Cell Rep Med · vol. 3 · número 10 · pág. 100777
- Editorial
- Elsevier BV
- Citado
- 108 citas · más que el 99% de estudios similares · 10.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 74 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Dietary Effects on Health · Diet and metabolism studies · Diet, Metabolism, and Disease
- Palabras clave
- Medicine, Dyslipidemia, Metabolic syndrome, Weight loss, Randomized controlled trial, Glycemic, Internal medicine, Endocrinology, Gastroenterology, Diabetes mellitus, Obesity
- MeSH
- humans, body weight, uric acid, blood glucose, intra-abdominal fat, dyslipidemias, diet, carbohydrate-restricted, metabolic syndrome
28 autores
- Mingqian He🇨🇳First Affiliated Hospital of Xi'an Jiaotong University; Xi'an Jiaotong University
- Jingya Wang🇨🇳First Affiliated Hospital of Xi'an Jiaotong University; Xi'an Jiaotong University
- Qian Liang🇨🇳First Affiliated Hospital of Xi'an Jiaotong University; Xi'an Jiaotong University
- Meng Li🇨🇳First Affiliated Hospital of Xi'an Jiaotong University; Xi'an Jiaotong University
- Hui Guo🇨🇳First Affiliated Hospital of Xi'an Jiaotong University; Xi'an Jiaotong University
- Yue Wang🇨🇳First Affiliated Hospital of Xi'an Jiaotong University; Xi'an Jiaotong University
- Yue Wang🇨🇳 · autor de correspondenciaFirst Affiliated Hospital of Xi'an Jiaotong University; Xi'an Jiaotong University
- Cuomu Deji🇨🇳First Affiliated Hospital of Xi'an Jiaotong University; Xi'an Jiaotong University
- Jing Sui🇨🇳First Affiliated Hospital of Xi'an Jiaotong University; Xi'an Jiaotong University
- Yawen Wang🇨🇳 · autor de correspondenciaFirst Affiliated Hospital of Xi'an Jiaotong University; Xi'an Jiaotong University
- Yawen Wang🇨🇳First Affiliated Hospital of Xi'an Jiaotong University; Xi'an Jiaotong University
- Yufeng Liu🇨🇳First Affiliated Hospital of Xi'an Jiaotong University; Xi'an Jiaotong University
- Yixuan Zheng🇨🇳First Affiliated Hospital of Xi'an Jiaotong University; Xi'an Jiaotong University
- Buyue Qian🇨🇳First Affiliated Hospital of Xi'an Jiaotong University; Xi'an Jiaotong University
- Huaixi Chen🇨🇳First Affiliated Hospital of Xi'an Jiaotong University; Xi'an Jiaotong University
- Mao Ma🇨🇳First Affiliated Hospital of Xi'an Jiaotong University; Xi'an Jiaotong University
- Su Shi🇨🇳First Affiliated Hospital of Xi'an Jiaotong University; Xi'an Jiaotong University
- Hui Geng🇨🇳First Affiliated Hospital of Xi'an Jiaotong University; Xi'an Jiaotong University
- Wenzhi Zhu🇨🇳First Affiliated Hospital of Xi'an Jiaotong University; Xi'an Jiaotong University
- Xiaoxiao Guo🇨🇳First Affiliated Hospital of Xi'an Jiaotong University; Xi'an Jiaotong University
- Wen-zhi Zhu🇨🇳First Affiliated Hospital of Xi'an Jiaotong University; Xi'an Jiaotong University
- Meng Zhang🇳🇱🇨🇳Leiden University Medical Center; First Affiliated Hospital of Xi'an Jiaotong University; Xi'an Jiaotong University
- Ziyi Chen🇨🇦🇨🇳University of Toronto; Hospital for Sick Children; First Affiliated Hospital of Xi'an Jiaotong University; SickKids Foundation; Xi'an Jiaotong University
- Patrick C.N. Rensen🇨🇳First Affiliated Hospital of Xi'an Jiaotong University; Xi'an Jiaotong University
- Chi-chung Hui🇨🇦🇨🇳University of Toronto; Hospital for Sick Children; First Affiliated Hospital of Xi'an Jiaotong University; SickKids Foundation; Xi'an Jiaotong University
- Yanan Wang🇨🇳First Affiliated Hospital of Xi'an Jiaotong University; Xi'an Jiaotong University
- Yanan Wang🇨🇳 · autor de correspondenciaFirst Affiliated Hospital of Xi'an Jiaotong University; Xi'an Jiaotong University
- Bingyin Shi🇨🇳 · autor de correspondenciaFirst Affiliated Hospital of Xi'an Jiaotong University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Overconsumption of carbohydrate-rich food combined with adverse eating patterns contributes to the increasing incidence of metabolic syndrome (MetS) in China. Therefore, we conducted a randomized trial to determine the effects of a low-carbohydrate diet (LCD), an 8-h time-restricted eating (TRE) schedule, and their combination on body weight and abdominal fat area (i.e., primary outcomes) and cardiometabolic outcomes in participants with MetS. Compared with baseline, all 3-month treatments significantly reduce body weight and subcutaneous fat area, but only TRE and combination treatment reduce visceral fat area (VFA), fasting blood glucose, uric acid (UA), and dyslipidemia. Furthermore, compared with changes of LCD, TRE and combination treatment further decrease body weight and VFA, while only combination treatment yields more benefits on glycemic control, UA, and dyslipidemia. In conclusion, without change of physical activity, an 8-h TRE with or without LCD can serve as an effective treatment for MetS (ClinicalTrials.gov: NCT04475822).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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