Metabolic profiles of ultra-processed food consumption and their role in obesity risk in British children
Handakas E, Chang K, Khandpur N, Vamos EP, Millett C, Sassi F, Vineis P, Robinson O
Clinical nutrition (Edinburgh, Scotland) · 45 citas
Etiquetas de revisión
Sin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio transversal (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Diarios o recordatorios de alimentación
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Wellcome Trust
- Gobierno
- UK Research and Innovation
- Gobierno
- National Institute for Health and Care Research
- Organización sin fines de lucro
- British Heart Foundation
- Gobierno
- Department of Health and Social Care
- Gobierno
- European Commission
- Universidad u hospital
- University of Bristol
- Gobierno
- National Institutes of Health
- Gobierno
- Medical Research Council
- Universidad u hospital
- School for Public Health Research
- Subvenciones
- School for Public Health Research (Grant Reference Number PD-SPH2015); University of Bristol (MC_UU_12013/1); European Commission (774548); Medical Research Council (217065/Z/19/Z); University of Bristol (217065/Z/19/Z); Wellcome Trust (076467); University of Bristol (076467); Medical Research Council (076467); Medical Research Council (MC_UU_12013); National Institute for Health and Care Research (MC_UU_12013/1); National Institute for Health and Care Research (217065/Z/19/Z); Wellcome Trust (217065/Z/19/Z); Medical Research Council (076467/Z/05/Z); Medical Research Council (217065); University of Bristol (092731); British Heart Foundation (PD-SPH-2015); European Commission (HORIZON2020); Medical Research Council (PD-SPH-2015); National Institutes of Health (092731); Medical Research Council (MCUU12013/1); Wellcome Trust (092731); National Institutes of Health (217065/Z/19/Z); School for Public Health Research (PD‐SPH‐2015); Department of Health and Social Care (PD-SPH-2015); National Institute for Health and Care Research (PD‐SPH‐2015); Medical Research Council (092731); Medical Research Council (5R01HL071248-07); Medical Research Council (MR/M501669/1); Wellcome Trust (217065); Wellcome Trust (PD-SPH-2015); Wellcome Trust (076467/Z05/z); Wellcome Trust (086676/Z/08/Z); National Institutes of Health (R01 DK077659); National Institutes of Health (DK077659)
Según 10 financiadores declarados.
Publicación
- Publicado
- 2022-09-15 · Clin Nutr · vol. 41 · número 11 · págs. 2537–2548
- Editorial
- Elsevier BV
- Citado
- 57 citas · más que el 98% de estudios similares · 8.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 77 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Consumer Attitudes and Food Labeling · Nutrition, Genetics, and Disease · Nutritional Studies and Diet
- Palabras clave
- Medicine, Obesity, Glutamine, Metabolic syndrome, Prospective cohort study, Metabolome, Internal medicine, Cohort, Endocrinology, Physiology, Food science, Amino acid, Metabolite, Biology, Biochemistry
- MeSH
- humans, citrates, fatty acids, monounsaturated, glutamine, amino acids, aromatic, diet, cross-sectional studies, food handling, child, metabolome, pediatric obesity
8 autores
- Evangelos Handakas🇬🇧Natural Environment Research Council; Imperial College London; Medical Research Council
- Kiara Chang🇬🇧Imperial College London
- Neha Khandpur🇺🇸🇧🇷Harvard University; Universidade de São Paulo
- Eszter Panna Vamos🇬🇧Imperial College London
- Christopher J. Millett🇬🇧🇬🇷Public Health England; National School of Public Health; Imperial College London
- Franco Sassi🇬🇧Imperial College London
- Paolo Vineis🇬🇧Natural Environment Research Council; Imperial College London; Medical Research Council
- Oliver Robinson🇬🇧 · autor de correspondenciaImperial College London; Medical Research Council
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background & aims
Higher consumption of ultra-processed foods (UPF) has been associated with childhood obesity, but underlying mechanisms remain unclear. We investigated plasma nuclear magnetic resonance metabolic profiles of higher UPF consumption and their role in obesity risk in the British ALSPAC cohort.
Methods
We performed cross-sectional and prospective metabolome wide association analyses of UPF, calculated from food diaries using the NOVA classification. In cross-sectional analysis, we tested the association between UPF consumption and metabolic profile at 7 years (N = 4528), and in the prospective analysis we tested the association between UPF consumption at 13 years and metabolic profile at 17 years (N = 3086). Effects of UPF-associated metabolites at 7 years on subsequent fat mass accumulation were assessed using growth curve models.
Results
At 7 years, UPF was associated with 115 metabolic traits including lower levels of branched-chain and aromatic amino acids and higher levels of citrate, glutamine, and monounsaturated fatty acids, which were also associated with greater fat mass accumulation. Reported intake of nutrients mediated associations with most metabolites, except for citrate.
Conclusions
UPF consumption among British children is associated with perturbation of multiple metabolic traits, many of which contribute to child obesity risk.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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