Financiado en parte por Human Clinical Research Facility at Texas A&M University from Specnova, Inc. (Boca Raton, FL, USA)
Effects of Acute Ashwagandha Ingestion on Cognitive Function
Xing D, Yoo C, Gonzalez D, Jenkins V, Nottingham K, Dickerson B, Leonard M, Ko J, Faries M, Kephart W, Purpura M, Jäger R, Sowinski R, Rasmussen CJ, Kreider RB
International journal of environmental research and public health · 33 citas
Etiquetas de revisión
Vínculos de autores con la industriaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Human Clinical Research Facility at Texas A&M University from Specnova, Inc. (Boca Raton, FL, USA)
- Universidad u hospital
- Exercise & Sport Nutrition Lab
- Autores
- Al menos un autor declara un vínculo económico con la industria
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-09-20 · Int J Environ Res Public Health · vol. 19 · número 19 · pág. 11852
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 47 citas · más que el 99% de estudios similares · 10.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 44 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Phytochemicals and Medicinal Plants · Food Science and Nutritional Studies · Medicinal Plants and Neuroprotection
- Palabras clave
- Ingestion, Cognition, Medicine, Poison control, Traditional medicine, Pharmacology, Medical emergency, Psychiatry, Internal medicine
- MeSH
- humans, withania, polyesters, plant extracts, cross-over studies, double-blind method, cognition, eating
15 autores
- Dante Xing🇺🇸Texas A&M University
- Choongsung Yoo🇺🇸Texas A&M University
- Drew Edward Gonzalez🇺🇸Texas A&M University
- Victoria M. Jenkins🇺🇸Texas A&M University
- Kay Nottingham🇺🇸Texas A&M University
- Broderick L. Dickerson🇺🇸Texas A&M University
- Megan Leonard🇺🇸Texas A&M University
- Joungbo Ko🇺🇸Texas A&M University
- Mark B. Faries🇺🇸Texas A&M University
- Wesley C. Kephart🇺🇸University of Wisconsin–Whitewater
- Martin Purpura🇺🇸Increnovo LLC (United States)
- Ralf Jäger🇺🇸Increnovo LLC (United States)
- Ryan J. Sowinski🇺🇸Texas A&M University
- Christopher J. Rasmussen🇺🇸Texas A&M University
- Richard B. Kreider🇺🇸 · autor de correspondenciaTexas A&M University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Ashwagandha (Withania somnifera) has been reported to decrease perceptions of stress, enhance mood, and improve cognitive function. However, it is currently unknown whether acute ashwagandha supplementation affects memory and cognitive function. This study evaluated the effects of acute ashwagandha extract ingestion on executive function.
Materials and methods
13 healthy volunteers were administered the Berg-Wisconsin Card Sorting (BCST), Go/No-Go (GNG), Sternberg Task (STT), and Psychomotor Vigilance Task (PVTT) tests. Participants then ingested in a double-blind, placebo-controlled, and crossover manner 400 mg of a placebo (PLA) or ashwagandha (ASH) extract (NooGandha®, Specnova Inc., Boca Raton, FL, USA). Participants then performed cognitive function tests every hour for 6 h. After a 4-day washout period, volunteers repeated the experiment while receiving the remaining supplement. Data were analyzed by repeated measures General Linear Model multivariate and univariate statistics with body weight as a covariate.
Results
Acute ASH supplementation increased STT-determined working memory as demonstrated by an improvement in 6 letter length, Present Reaction Time at 3 and 6 h. PVTT analysis revealed that ASH sustained attention by helping maintain reaction times, preventing mental fatigue, and remaining vigilant. Conversely, reaction times (at task 20, hour 6; overall, hour 3) increased with PLA. In the BCST, there was evidence that ASH increased the ability to recognize and 'shift' to a new rule compared with baseline. However, this was not seen when evaluating changes from baseline, suggesting that differences in baseline values influence results. In the GNG test, ASH ingestion promoted faster response times to respond correctly than PLA, indicating less metal fatigue. However, ASH did not affect accuracy compared to PLA, as both treatments decreased the percentage of correct answers.
Conclusions
Acute supplementation with 400 mg of ashwagandha improved selected measures of executive function, helped sustain attention, and increased short-term/working memory.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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