Effects of time-restricted feeding (16/8) combined with a low-sugar diet on the management of non-alcoholic fatty liver disease: A randomized controlled trial
Kord-Varkaneh H, Salehi-Sahlabadi A, Tinsley GM, Santos HO, Hekmatdoost A
Nutrition (Burbank, Los Angeles County, Calif.) · 64 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Shahid Beheshti University of Medical Sciences
- Universidad u hospital
- National Nutrition and Food Technology Research Institute
- Universidad u hospital
- Gastrointestinal and Liver Diseases Research Center
- Universidad u hospital
- Shahid Beheshti University of Medical Sciences Research Institute for Gastroenterology and Liver Diseases
Según 4 financiadores declarados.
Publicación
- Publicado
- 2022-09-13 · Nutrition · vol. 105 · pág. 111847
- Editorial
- Elsevier BV
- Citado
- 83 citas · más que el 99% de estudios similares · 9.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 103 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dietary Effects on Health · Liver Disease Diagnosis and Treatment · Diet, Metabolism, and Disease
- Palabras clave
- time-restricted feeding, low-sugar diet, non-alcoholic fatty liver disease, fasting-mimicking diet, liver fibrosis, cardiometabolic biomarkers, inflammatory markers, body composition, cardiometabolic risk, dietary intervention, alanine aminotransferase, C-reactive protein, cytokeratin 18, controlled attenuation parameter
- MeSH
- liver, humans, cardiovascular diseases, cholesterol, diet, fasting, non-alcoholic fatty liver disease, sugars
5 autores
- Hamed Kord‐Varkaneh🇮🇷Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
- Ammar Salehi‐Sahlabadi🇮🇷Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
- Grant M. Tinsley🇺🇸Texas Tech University
- Heitor Oliveira Santos🇧🇷Universidade Federal de Uberlândia
- Azita Hekmatdoost🇮🇷 · autor de correspondenciaShahid Beheshti University; Shahid Beheshti University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
Emerging studies have employed time-restricted feeding (TRF) and a low-sugar diet alone in the management of non-alcoholic fatty liver disease (NAFLD), but their combination has not been tested. The aim of this study was to investigate the effects of TRF combined with a low-sugar diet on NAFLD parameters, cardiometabolic and inflammatory biomarkers, and body composition in patients with NAFLD.
Methods
A 12-wk randomized controlled trial was performed to compare the effects of TRF (16 h fasting/8 h feeding daily [16/8]) plus a low-sugar diet versus a control diet based on traditional meal distribution in patients with NAFLD. Changes in body composition, anthropometric indices, and liver and cardiometabolic markers were investigated.
Results
TRF 16/8 with a low-sugar diet reduced body fat (26.7 ± 5.4 to 24.2 ± 4.9 kg), body weight (83.8 ± 12.7 to 80.5 ± 12.1 kg), waist circumference (104.59 ± 10.47 to 101.91 ± 7.42 cm), and body mass index (29.1 ± 2.6 to 28 ± 2.7 kg/m2), as well as circulating levels of fasting blood glucose and liver (alanine aminotransferase, 34 ± 13.9 to 21.2 ± 5.4 U/L; aspartate aminotransferase, 26.3 ± 6.2 to 20.50 ± 4 U/L; γ-glutamyl transpeptidase, 33 ± 15 to 23.2 ± 11.1 U/L; fibrosis score, 6.3 ± 1 to 5.2 ± 1.2 kPa; and controlled attenuation parameter, 322.9 ± 34.9 to 270.9 ± 36.2 dB/m), lipids (triacylglycerols, 201.5 ± 35.3 to 133.3 ± 48.7 mg/dL; total cholesterol, 190 ± 36.6 to 157.8 ± 33.6 mg/dL; and low-density lipoprotein cholesterol, 104.6 ± 27.3 to 84 ± 26.3 mg/dL), and inflammatory markers (high-sensitivity C-reactive protein, 3.1 ± 1.1 to 2 ± 0.9 mg/L; and cytokeratin-18, 1.35 ± 0.03 to 1.16 ± 0.03 ng/mL). These results were statistically significant (P < 0.05) compared with the control group.
Conclusions
TRF plus a low-sugar diet can reduce adiposity and improve liver, lipid, and inflammatory markers in patients with NAFLD.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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