Intake of Ultra-processed Foods Is Associated with an Increased Risk of Crohn's Disease: A Cross-sectional and Prospective Analysis of 187 154 Participants in the UK Biobank
Chen J, Wellens J, Kalla R, Fu T, Deng M, Zhang H, Yuan S, Wang X, Theodoratou E, Li X, Satsangi J
Journal of Crohn's & colitis · 90 citas
Etiquetas de revisión
Sin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Diarios o recordatorios de alimentación
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Key Project of Research and Development Plan of Hunan Province
- Organización sin fines de lucro
- Cancer Research UK
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Medical Research Council
- Gobierno
- Science Fund for Distinguished Young Scholars of Zhejiang Province
- Gobierno
- Natural Science Fund for Distinguished Young Scholars of Zhejiang Province
- Subvenciones
- Key Project of Research and Development Plan of Hunan Province (2019SK 2041); Cancer Research UK (C31250/A22804); National Natural Science Foundation of China (81970494); Cancer Research UK (66354); Medical Research Council (MC_PC_17228); Science Fund for Distinguished Young Scholars of Zhejiang Province (C31250/A22804); Key Project of Research and Development Plan of Hunan Province (81970494); Science Fund for Distinguished Young Scholars of Zhejiang Province (LR22H260001); National Natural Science Foundation of China (2019SK2041); Cancer Research UK (22804)
Según 6 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2022-10-25 · J Crohns Colitis · vol. 17 · número 4 · págs. 535–552
- Editorial
- Oxford University Press
- Citado
- 115 citas · más que el 100% de estudios similares · 18.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (revista híbrida) · OTHER-OA
- Áreas de investigación
- Consumer Attitudes and Food Labeling · Nutritional Studies and Diet · Health, Technology, Consumer Behavior
- Palabras clave
- Medicine, Hazard ratio, Incidence (geometry), Internal medicine, Ulcerative colitis, Prospective cohort study, Odds ratio, Confidence interval, Inflammatory bowel disease, Crohn's disease, Cross-sectional study, Logistic regression, Proportional hazards model, Cohort, Disease, Pathology
- MeSH
- humans, colitis, ulcerative, inflammatory bowel diseases, crohn disease, risk factors, prospective studies, cross-sectional studies, middle aged, biological specimen banks, united kingdom, food, processed
11 autores
- Jie Chen🇨🇳Central South University; Third Xiangya Hospital; Second Affiliated Hospital of Zhejiang University
- Judith Wellens🇬🇧🇧🇪John Radcliffe Hospital; KU Leuven
- Rahul Kalla🇬🇧Centre for Inflammation Research; Medical Research Council; University of Edinburgh
- Tian Fu🇨🇳Central South University; Third Xiangya Hospital
- Minzi Deng🇨🇳Central South University; Third Xiangya Hospital
- Han Zhang🇨🇳Second Affiliated Hospital of Zhejiang University
- Shuai Yuan🇸🇪Karolinska Institutet
- Xiaoyan Wang🇨🇳 · autor de correspondenciaCentral South University; Third Xiangya Hospital
- Evropi Τheodoratou🇬🇧Edinburgh Cancer Research; Institute of Genetics and Cancer; University of Edinburgh
- Xue Li🇨🇳 · autor de correspondenciaSecond Affiliated Hospital of Zhejiang University
- Jack Satsangi🇬🇧John Radcliffe Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and aims
Ultra-processed food [UPF] consumption has been linked to globally increasing incidence and prevalence of chronic diseases, including inflammatory bowel diseases [IBD]. We aimed to investigate the association between UPF consumption and IBD incidence, prevalence, and IBD-relevant outcomes.
Methods
We performed a cross-sectional and prospective cohort study in 187 854 individuals included in the national UK Biobank, using 24-h dietary recall questionnaires. Multivariable logistic regression and Cox proportional hazard regression were used to examine the association between UPFs and the prevalence and incidence risk of IBD, respectively.
Results
A total of 185 849 participants with a mean age of 56.2 were included, with a mean follow-up of 9.84 years. During follow-up, 841 developed IBD (251 Crohn's disease [CD], and 590 ulcerative colitis [UC]). UPF intake in IBD patients was significantly higher: CD: odds ratio [OR] 1.94 (95% confidence interval [CI]: 1.52, 2.49, p <0.001); UC: OR 1.39 [95% CI: 1.17, 1.65, p <0.001]. Compared with low consumption, higher UPF consumption was significantly associated with incident CD: hazard ration [HR] 2.00 [95% CI: 1.32, 3.03, p = 0.001], but not UC. We also found a significant association between UPF intake and need of IBD-related surgery: HR 4.06 [95% CI: 1.52, 10.86, p = 0.005].
Conclusion
Higher intake of UPFs was associated with higher incidence of CD, but not UC. In individuals with a pre-existing diagnosis of IBD, consumption of UPFs was significantly higher compared with controls, and was associated with an increased need for IBD-related surgery. Further studies are needed to address the impact of UPF intake on disease pathogenesis and outcomes.
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